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Axon-like protrusions promote small cell lung cancer migration and metastasis
- Source :
- eLife, Vol 8 (2019), eLife
- Publication Year :
- 2019
- Publisher :
- eScholarship, University of California, 2019.
-
Abstract
- Metastasis is the main cause of death in cancer patients but remains a poorly understood process. Small cell lung cancer (SCLC) is one of the most lethal and most metastatic cancer types. SCLC cells normally express neuroendocrine and neuronal gene programs but accumulating evidence indicates that these cancer cells become relatively more neuronal and less neuroendocrine as they gain the ability to metastasize. Here we show that mouse and human SCLC cells in culture and in vivo can grow cellular protrusions that resemble axons. The formation of these protrusions is controlled by multiple neuronal factors implicated in axonogenesis, axon guidance, and neuroblast migration. Disruption of these axon-like protrusions impairs cell migration in culture and inhibits metastatic ability in vivo. The co-option of developmental neuronal programs is a novel molecular and cellular mechanism that contributes to the high metastatic ability of SCLC.
- Subjects :
- 0301 basic medicine
Lung Neoplasms
Mouse
Medizin
migration
Axonogenesis
Metastasis
Mice
0302 clinical medicine
Cell Movement
cell biology
Tumor Cells, Cultured
2.1 Biological and endogenous factors
Axon
Biology (General)
Neoplasm Metastasis
Aetiology
Lung
Cancer Biology
cancer biology
Cancer
Cultured
General Neuroscience
Lung Cancer
SCLC
Cell migration
General Medicine
protrusions
3. Good health
Tumor Cells
medicine.anatomical_structure
030220 oncology & carcinogenesis
Medicine
Research Article
Human
Biotechnology
QH301-705.5
Science
Biology
General Biochemistry, Genetics and Molecular Biology
neuronal
03 medical and health sciences
Rare Diseases
Neuroblast migration
medicine
Animals
Humans
metastasis
neuroendocrine
human
mouse
General Immunology and Microbiology
Neurosciences
Cell Biology
medicine.disease
Small Cell Lung Carcinoma
respiratory tract diseases
030104 developmental biology
nervous system
Cancer cell
Cancer research
Axon guidance
Cell Surface Extensions
Biochemistry and Cell Biology
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- eLife, Vol 8 (2019), eLife
- Accession number :
- edsair.doi.dedup.....b63edc532a587b2bf34e12f536f7d6e6