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Severe Renal Impairment Has Minimal Impact on Doravirine Pharmacokinetics
- Source :
- Antimicrobial agents and chemotherapy. 62(8)
- Publication Year :
- 2018
-
Abstract
- Doravirine is a novel nonnucleoside reverse transcriptase inhibitor in development for use with other antiretroviral therapies to treat human immunodeficiency virus type 1 (HIV-1) infection. Doravirine metabolism predominantly occurs via cytochrome P450 3A with
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Anti-HIV Agents
Pyridones
030106 microbiology
Urology
Cmax
Renal function
Kidney
Severity of Illness Index
Antiviral Agents
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Pharmacokinetics
Doravirine
Medicine
Humans
Pharmacology (medical)
030212 general & internal medicine
Renal Insufficiency, Chronic
Aged
Pharmacology
Reverse-transcriptase inhibitor
business.industry
Area under the curve
Middle Aged
Triazoles
Confidence interval
Infectious Diseases
chemistry
Area Under Curve
Case-Control Studies
Female
Geometric mean
business
medicine.drug
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 10986596
- Volume :
- 62
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Antimicrobial agents and chemotherapy
- Accession number :
- edsair.doi.dedup.....b613701072cf8c34b136e4f43e41d19e