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Diagnostic Value of Vascular Endothelial Growth Factor, Transforming Growth Factor-β, Interleukin-8, and the Ratio of Lactate Dehydrogenase to Adenosine Deaminase in Pleural Effusion
- Source :
- Lung. 196(2)
- Publication Year :
- 2017
-
Abstract
- We studied the diagnostic value of cytokines, including vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β), and interleukin-8 (IL-8), and the ratio of lactate dehydrogenase (LDH) to adenosine deaminase (ADA) in pleural fluid. Prospective analysis of 44 inpatients or outpatients with pleural fluid, from December 2016 to March 2017 was conducted. We enrolled patients with malignant pleural effusion (MPE, N = 15), empyema (N = 11), parapneumonic effusion (PPE, N = 7), chronic renal failure (CRF)/chronic heart failure (CHF) (N = 7), and tuberculous pleural effusion (TBPE, N = 4). The pleural fluid values of IL-8 and VEGF were significantly higher in empyema patients than in CRF/CHF or PPE patients. In all patients, the pleural fluid VEGF and IL-8 values were significantly positively correlated (r = 0.405, p = 0.006; r = 0.474, p = 0.047, respectively). TGF-β was elevated in patients with empyema, PPE, TBPE, and MPE. The pleural LDH-to-ADA ratio in patients with MPE or empyema/PPE was significantly higher than in patients with CRF/CHF or TBPE. LDH and ADA levels correlated significantly only in patients with MPE (r = 0.648, p = 0.009) and empyema/PPE (r = 0.978, p
- Subjects :
- Pulmonary and Respiratory Medicine
Male
Vascular Endothelial Growth Factor A
medicine.medical_specialty
Pleural effusion
Adenosine Deaminase
Gastroenterology
Parapneumonic effusion
Diagnosis, Differential
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Predictive Value of Tests
Transforming Growth Factor beta
Lactate dehydrogenase
Internal medicine
medicine
Malignant pleural effusion
Humans
Tuberculosis
Prospective Studies
Empyema, Pleural
Aged
Aged, 80 and over
Heart Failure
L-Lactate Dehydrogenase
business.industry
Interleukin-8
Pneumonia
respiratory system
Pleural cavity
Middle Aged
medicine.disease
Empyema
respiratory tract diseases
Pleural Effusion, Malignant
Vascular endothelial growth factor
Pleural Effusion
medicine.anatomical_structure
030228 respiratory system
chemistry
030220 oncology & carcinogenesis
Heart failure
Kidney Failure, Chronic
Female
business
Biomarkers
Subjects
Details
- ISSN :
- 14321750
- Volume :
- 196
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Lung
- Accession number :
- edsair.doi.dedup.....b6129104a2258e6d6f0fe1b3d5aba80d