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Superior outcome for splenectomised patients in a population-based study of splenic marginal zone lymphoma in Sweden
- Publication Year :
- 2021
- Publisher :
- Uppsala universitet, Institutionen för immunologi, genetik och patologi, 2021.
-
Abstract
- Splenic marginal zone lymphoma (SMZL) is a rare low-grade B-cell lymphoma where associations with viral hepatitis and autoimmune and inflammatory diseases (AID) have been indicated. We aimed at assessing the prevalence of viral hepatitis and AID at SMZL diagnosis and outcome by treatment in a Swedish population-based study. A total of 277 SMZL patients registered in the Swedish Lymphoma Register in 2007-2017 were included. A history of viral hepatitis was reported in five (2%) patients and AID prior to SMZL in 72/240 (30%) patients. Treatment was given up front for 207 (75%) patients. Splenectomy with or without systemic treatment was performed in 119 (57%) and was associated with statistically significantly better overall survival [hazard ratio, HR = 0 center dot 47 (95% confidence interval, CI: 0 center dot 23-0 center dot 93), P = 0 center dot 03] and progression-free survival (HR = 0 center dot 55, 95% CI: 0 center dot 35-0 center dot 86, P = 0 center dot 008) compared to non-splenectomised patients in multivariable analyses. The up-front splenectomised group was younger and generally had a lower Ann Arbor stage, but also more frequently B symptoms and high lactate dehydrogenase than the non-splenectomised group. Viral hepatitis and AID history did not affect SMZL outcome. We report high incidence of AIDs and low incidence of viral hepatitis in this population-based study of SMZL. Splenectomy up front was associated with a favourable outcome.
- Subjects :
- Male
medicine.medical_specialty
Population
splenic marginal zone lymphoma
splenectomy
Autoimmune Diseases
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Prospective Studies
Splenic marginal zone lymphoma
Hematologi
education
Sweden
education.field_of_study
Cancer och onkologi
treatment
business.industry
Clinical Laboratory Medicine
Splenic Neoplasms
Incidence (epidemiology)
Hazard ratio
Lymphoma, B-Cell, Marginal Zone
Hepatitis C
Hematology
Middle Aged
Hepatitis B
medicine.disease
Klinisk laboratoriemedicin
Treatment Outcome
B symptoms
030220 oncology & carcinogenesis
Cancer and Oncology
Splenectomy
Female
hepatitis B
medicine.symptom
hepatitis C
Viral hepatitis
business
030215 immunology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....b611886815479c8cdfae3625190c7da5