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Inflammatory mechanisms in neurodegeneration
- Source :
- J Neurochem, Journal of neurochemistry 149(5), 562-581 (2019). doi:10.1111/jnc.14674
- Publication Year :
- 2018
-
Abstract
- This review discusses the profound connection between microglia, neuroinflammation, and Alzheimer’s disease (AD)(). Theories have been postulated, tested, and modified over several decades. The findings have further bolstered the belief that microglia-mediated inflammation is both a product and contributor to AD pathology and progression. Distinct microglia phenotypes and their function, microglial recognition and response to protein aggregates in AD, and the overall role of microglia in AD are research areas that have received considerable research attention and yielded significant results. The following article provides a historical perspective of microglia, a detailed discussion of multiple microglia phenotypes including dark microglia, and a review of a number of areas where microglia intersect with AD and other pathological neurological processes. The overall breadth of important discoveries achieved in these areas significantly strengthens the hypothesis that neuroinflammation plays a key role in AD. Future determination of the exact mechanisms by which microglia respond to, and attempt to mitigate, protein aggregation in AD may lead to new therapeutic strategies.
- Subjects :
- 0301 basic medicine
Amyloid beta
immunology [Nerve Degeneration]
Inflammation
Disease
metabolism [Microglia]
Biochemistry
Article
pathology [Alzheimer Disease]
03 medical and health sciences
Cellular and Molecular Neuroscience
immunology [Inflammation]
0302 clinical medicine
Alzheimer Disease
medicine
Animals
Humans
ddc:610
Neuroinflammation
Microglia
biology
business.industry
Neurodegeneration
pathology [Nerve Degeneration]
medicine.disease
immunology [Microglia]
immunology [Alzheimer Disease]
030104 developmental biology
medicine.anatomical_structure
nervous system
Nerve Degeneration
biology.protein
medicine.symptom
business
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14714159
- Volume :
- 149
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of neurochemistry
- Accession number :
- edsair.doi.dedup.....b60e262d39f86beb0f5cdf7f24c885b5