Back to Search
Start Over
Evaluation of Platelet Activation, Coagulation, and Fibrinolytic Activation in Patients With Symptomatic Lacunar Stroke
- Source :
- The Neurologist. 16:188-191
- Publication Year :
- 2010
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2010.
-
Abstract
- BACKGROUND It is unclear whether hemostasis plays a role in the pathogenesis of ischemic stroke subtypes. OBJECTIVE We aimed to investigate the possible relationship between different hemostatic markers and lacunar stroke. RESULTS The study consisted of 30 patients with symptomatic lacunar stroke and 30 healthy age-matched healthy individuals. We analyzed the values of "Mean Platelet Volume," D-dimer, "soluble p-selectin," "Plasminogen Activator Inhibitor Type-1" (PAI-1), "Thrombin-Activatable Fibrinolysis Inhibitor" (TAFI), and "Platelet Factor 4" (PF4) in patients with lacunar infarct and compared these values to those of control individuals. There were significant differences for D-dimer, mean platelet volume, thrombin-activatable fibrinolysis inhibitor, and platelet factor 4 values in symptomatic lacunar stroke group compared with the control group (P < 0.01). CONCLUSIONS Different hemostatic factors may play a role in the pathogenesis of lacunar stroke. Evaluating the role of hemostatic factors on different types of strokes may help us identify new therapeutic strategies and different prognostic stratifications for ischemic stroke.
- Subjects :
- Brain Infarction
Male
Carboxypeptidase B2
medicine.medical_specialty
Lacunar stroke
genetic structures
Platelet Factor 4
Brain Ischemia
Fibrin Fibrinogen Degradation Products
Pathogenesis
Predictive Value of Tests
Internal medicine
Plasminogen Activator Inhibitor 1
Humans
Medicine
cardiovascular diseases
Platelet activation
Mean platelet volume
Aged
Aged, 80 and over
Hemostasis
Coagulation
Symptomatic lacunar stroke
business.industry
General Medicine
Blood Coagulation Disorders
Middle Aged
Prognosis
medicine.disease
P-Selectin
Fibrinolytic activation
Cardiology
Female
Neurology (clinical)
business
Plasminogen activator
Biomarkers
Platelet factor 4
Subjects
Details
- ISSN :
- 10747931
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- The Neurologist
- Accession number :
- edsair.doi.dedup.....b5fecbef555555f12b991cb13d060eae