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Inhibitory effect of black chokeberry fruit polyphenols on pancreatic lipase – Searching for most active inhibitors
- Source :
- Journal of Functional Foods, Vol 49, Iss, Pp 196-204 (2018)
- Publication Year :
- 2018
- Publisher :
- Elsevier, 2018.
-
Abstract
- In this study, the effects of a chokeberry fruit crude extract (CE), its ethyl acetate fractions (EAF7 & EAF2) and a polyphenol-rich fraction (PRF) on esterase and lipolytic activities of pancreatic lipase (PL) were investigated. Ethyl acetate fractions, rich in flavonols, phenolic acids and low molecular procyanidins, showed a week inhibitory activity against PL while the CE and PRF, which contained the highly polymerized procyanidins exhibited the highest anti-lipase activity. The kinetic study showed that the inhibitory mode of CE was noncompetitive while PRF behaved like the mixed type inhibitor. Cumulative effects were observed when orlistat was used with either CE or PRF. These results indicate that black chokeberry fruits are a source of PL inhibitors with proanthocyanidins as the most active compounds.
- Subjects :
- 0301 basic medicine
Ethyl acetate
Medicine (miscellaneous)
Esterase
UPLC-MS
03 medical and health sciences
chemistry.chemical_compound
Flavonols
medicine
Phenolics profile
Pancreatic lipase
TX341-641
Food science
chemistry.chemical_classification
030109 nutrition & dietetics
Nutrition and Dietetics
biology
Inhibitors
Nutrition. Foods and food supply
digestive system diseases
Orlistat
Proanthocyanidin
chemistry
Polyphenol
biology.protein
Black chokeberry
Black chokeberry fruits
Food Science
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 17564646
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Journal of Functional Foods
- Accession number :
- edsair.doi.dedup.....b5f5dc4a3d66adcc62600b7c4cdf3999