Back to Search
Start Over
Role of ion channels in ionizing radiation-induced cell death
- Source :
- Biochimica et biophysica acta. 1848(10 Pt)
- Publication Year :
- 2014
-
Abstract
- Neoadjuvant, adjuvant or definitive fractionated radiation therapy are implemented in first line anti-cancer treatment regimens of many tumor entities. Ionizing radiation kills the tumor cells mainly by causing double strand breaks of their DNA through formation of intermediate radicals. Survival of the tumor cells depends on both, their capacity of oxidative defense and their efficacy of DNA repair. By damaging the targeted cells, ionizing radiation triggers a plethora of stress responses. Among those is the modulation of ion channels such as Ca2+-activated K+ channels or Ca2+-permeable nonselective cation channels belonging to the super-family of transient receptor potential channels. Radiogenic activation of these channels may contribute to radiogenic cell death as well as to DNA repair, glucose fueling, radiogenic hypermigration or lowering of the oxidative stress burden. The present review article introduces these channels and summarizes our current knowledge on the mechanisms underlying radiogenic ion channel modulation. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers.
- Subjects :
- Ca2+-activated K+ channels
Programmed cell death
DNA Repair
DNA repair
Biophysics
Oxidative phosphorylation
medicine.disease_cause
Biochemistry
Radiation Tolerance
Ionizing radiation
Transient receptor potential channel
Potassium Channels, Calcium-Activated
Transient Receptor Potential Channels
Neoplasms
Radiation, Ionizing
medicine
Humans
Ion transporter
Ion channel
Ion transport
Cancer
Radiation
Cell Death
Chemistry
Therapy resistance
Cell Biology
DNA, Neoplasm
Neoadjuvant Therapy
Gene Expression Regulation, Neoplastic
Treatment Outcome
Immunology
Cancer research
Radiotherapy, Adjuvant
Oxidative stress
DNA Damage
Signal Transduction
Subjects
Details
- ISSN :
- 00063002
- Volume :
- 1848
- Issue :
- 10 Pt
- Database :
- OpenAIRE
- Journal :
- Biochimica et biophysica acta
- Accession number :
- edsair.doi.dedup.....b5dfb49fc741aa54053e3268abba59f8