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The Shaping of T Cell Receptor Recognition by Self-Tolerance
- Source :
- Immunity. (2):193-203
- Publisher :
- Elsevier Inc.
-
Abstract
- SummaryDuring selection of the T cell repertoire, the immune system navigates the subtle distinction between self-restriction and self-tolerance, yet how this is achieved is unclear. Here we describe how self-tolerance toward a trans-HLA (human leukocyte antigen) allotype shapes T cell receptor (TCR) recognition of an Epstein-Barr virus (EBV) determinant (FLRGRAYGL). The recognition of HLA-B8-FLRGRAYGL by two archetypal TCRs was compared. One was a publicly selected TCR, LC13, that is alloreactive with HLA-B44; the other, CF34, lacks HLA-B44 reactivity because it arises when HLA-B44 is coinherited in trans with HLA-B8. Whereas the alloreactive LC13 TCR docked at the C terminus of HLA-B8-FLRGRAYGL, the CF34 TCR docked at the N terminus of HLA-B8-FLRGRAYGL, which coincided with a polymorphic region between HLA-B8 and HLA-B44. The markedly contrasting footprints of the LC13 and CF34 TCRs provided a portrait of how self-tolerance shapes the specificity of TCRs selected into the immune repertoire.
- Subjects :
- Models, Molecular
Herpesvirus 4, Human
T cell
Immunology
Receptors, Antigen, T-Cell
chemical and pharmacologic phenomena
Human leukocyte antigen
Biology
Crystallography, X-Ray
Epitope
HLA-B8 Antigen
Immune system
Antigen
medicine
Immunology and Allergy
Humans
Amino Acid Sequence
Receptor
Protein Structure, Quaternary
Antigens, Viral
Genetics
T-cell receptor
hemic and immune systems
Surface Plasmon Resonance
Allotype
MOLIMMUN
Infectious Diseases
medicine.anatomical_structure
Self Tolerance
Structural Homology, Protein
Peptides
Subjects
Details
- Language :
- English
- ISSN :
- 10747613
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Immunity
- Accession number :
- edsair.doi.dedup.....b5d29db18c53548a231cf8221929dd46
- Full Text :
- https://doi.org/10.1016/j.immuni.2008.11.011