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Long-Term Follow-up Results of Renal Transplantation in Pediatric Patients With Focal Segmental Glomerulosclerosis: A Single-Center Experience
- Source :
- Transplantation Proceedings. 51:1064-1069
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- 12th Congress of the Turkish-Transplantation-Centers-Coordination-Association (TTCCA) -- OCT 18-21, 2018 -- Trabzon, TURKEY<br />Taner, Sevgin/0000-0003-1578-789X<br />WOS: 000500179300012<br />PubMed: 31101172<br />Introduction and Aim. Focal segmental glomerulosclerosis (FSGS) is a common cause of end-stage renal disease in children. We analyzed the long-term outcome of pediatric patients with FSGS undergoing renal transplantation. the objective of the study is to report the experience of a single center and determine the incidence of recurrence, rejection, graft loss, and related risk factors. Materials and Method. This retrospective cohort study was performed between 1991 and 2018. Thirty patients with a pathologic diagnosis of primary FSGS were included in the study. the patients were diagnosed with FSGS according to histologic features in biopsies. Results. Twenty-one of the donors were deceased (70%) and 9 were alive (30%). FSGS recurred in only 2 patients. Graft loss occurred in 6 patients (20%). the causes of graft loss were chronic rejection in 4 patients and acute rejection in 2. Our graft survival rate was 100% at 1 year, 91% at 5 years, 80% at 10 years, 70% at 15 years, and 42% at 20 years. Five- and 10-year graft survival rates were 83% and 83% in living donors and 94% and 79% in deceased donors, respectively. According to Kaplan-Meier analysis, there was no statistically significant difference in terms of graft survival between living and deceased donors. Conclusion. This study, with its contribution to literature in terms of long follow-up of FSGS patients from childhood to adulthood, is important. However, further studies are required.<br />Turkish Transplantat Ctr Coordinat Assoc
- Subjects :
- Male
medicine.medical_specialty
Adolescent
Long term follow up
Disease
urologic and male genital diseases
Single Center
Cohort Studies
Primary FSGS
Young Adult
Focal segmental glomerulosclerosis
Recurrence
Risk Factors
medicine
Humans
Child
Retrospective Studies
Transplantation
Glomerulosclerosis, Focal Segmental
business.industry
Incidence (epidemiology)
Graft Survival
Infant
Retrospective cohort study
medicine.disease
Kidney Transplantation
Surgery
Child, Preschool
Female
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 00411345
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Transplantation Proceedings
- Accession number :
- edsair.doi.dedup.....b5d1e12fc3d165dd65f494768872f122