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A European Respiratory Society technical standard: exhaled biomarkers in lung disease

Authors :
Marco Santonico
Hugo H. Knobel
Kim D G van de Kant
Anh Tuan Dinh-Xuan
Stephen J. Fowler
C. Bucca
Marc P. van der Schee
Teunis J. Vink
Andras Bikov
Eugenio Baraldi
Stelios Loukides
Konstantinos Kostikas
Lauri Lehtimäki
Johan C. de Jongste
Fabio Luigi Massimo Ricciardolo
Petra Reinhold
Simona M. Cristescu
Frederik-Jan van Schooten
Jon O. Lundberg
Paul Brinkman
Quirijn Jöbsis
Olaf Holz
Anton Amann
Niki Fens
Antonio Spanevello
Alain Van Muylem
Giovanna Elisiana Carpagnano
Philippe P.R. Rosias
Edward Dompeling
Giorgio Pennazza
Jens M. Hohlfeld
Thomy Tonia
Agnes W. Boots
Peter J. Barnes
Balazs Antus
Anna-Carin Olin
Paolo Montuschi
Peter J. Sterk
Marieann Högman
Lieuwe D. J. Bos
Ildiko Horvath
Massimo Corradi
Farmacologie en Toxicologie
RS: NUTRIM - R3 - Respiratory & Age-related Health
RS: NUTRIM - R4 - Gene-environment interaction
MUMC+: MA Medische Staf Kindergeneeskunde (9)
RS: CAPHRI - R5 - Optimising Patient Care
Kindergeneeskunde
Family Medicine
AII - Inflammatory diseases
Other departments
Graduate School
APH - Methodology
ARD - Amsterdam Reproduction and Development
ACS - Heart failure & arrhythmias
Pediatrics
Publica
Source :
European Respiratory Journal, 49(4):1600965. European Respiratory Society, European Respiratory Journal, 49, 1-26, European respiratory journal, 49(4). European Respiratory Society, European Respiratory Journal, 49, 4, pp. 1-26
Publication Year :
2017

Abstract

Breath tests cover the fraction of nitric oxide in expired gas (FENO), volatile organic compounds (VOCs), variables in exhaled breath condensate (EBC) and other measurements. For EBC and for FENO, official recommendations for standardised procedures are more than 10 years old and there is none for exhaled VOCs and particles. The aim of this document is to provide technical standards and recommendations for sample collection and analytic approaches and to highlight future research priorities in the field. For EBC and FENO, new developments and advances in technology have been evaluated in the current document. This report is not intended to provide clinical guidance on disease diagnosis and management.Clinicians and researchers with expertise in exhaled biomarkers were invited to participate. Published studies regarding methodology of breath tests were selected, discussed and evaluated in a consensus-based manner by the Task Force members.Recommendations for standardisation of sampling, analysing and reporting of data and suggestions for research to cover gaps in the evidence have been created and summarised.Application of breath biomarker measurement in a standardised manner will provide comparable results, thereby facilitating the potential use of these biomarkers in clinical practice.

Details

Language :
English
ISSN :
09031936
Database :
OpenAIRE
Journal :
European Respiratory Journal, 49(4):1600965. European Respiratory Society, European Respiratory Journal, 49, 1-26, European respiratory journal, 49(4). European Respiratory Society, European Respiratory Journal, 49, 4, pp. 1-26
Accession number :
edsair.doi.dedup.....b5caa8b5e618c4a4fb895765d6f717cd