Back to Search
Start Over
Dopaminergic Degeneration and Small Vessel Disease in Patients with Normal Pressure Hydrocephalus Who Underwent Shunt Surgery
- Source :
- Journal of Clinical Medicine, Volume 9, Issue 4, Journal of Clinical Medicine, Vol 9, Iss 1084, p 1084 (2020)
- Publication Year :
- 2020
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2020.
-
Abstract
- The diagnosis of idiopathic normal pressure hydrocephalus (iNPH) and the outcome of lumboperitoneal shunt treatment remains to be systematically explored. Here, we aim to evaluate whether the severity of dopaminergic degeneration and white matter small vessel disease could be predictors of outcome for iNPH patients subjected to lumboperitoneal shunt treatment. This is a single center retrospective study with 39 patients with probable iNPH undergoing programmable surgical lumboperitoneal shunt from June 2016 to March 2018 at Hualien Tzu Chi Hospital. In all patients, dopaminergic degeneration was determined with 99mTc- TRODAT-1 SPECT scan, while white matter small vessel disease (Fazekas scale) was assessed with Brain MRI. The iNPH grading scale (iNPHGS) score and Karnofsky Performance Score (KPS) pre- and post-operation (6-month follow-up) were available for all patients. Linear regression was used to correlate the severities of dopaminergic degeneration and small vessel disease with lumboperitoneal shunt treatment outcomes. Their iNPHGS score improved significantly after surgery (pre-operatively, 7.8 &plusmn<br />2.6<br />post-operatively, 5.7 &plusmn<br />2.6 (26.9% improvement) (p &lt<br />0.05)). Moreover, the KPS was also improved significantly after surgery, by a mean of 24.6% from the baseline score (p &lt<br />0.05). A significant correlation was observed between the severity of dopaminergic degeneration and a poorer improvement of iNPHGS score (p = 0.03). However, improvement of the iNPHGS score was not correlated with white matter small vessel disease. Dopaminergic degeneration comorbidity neutralized the degree of improvement after surgery. Although white matter small vessel disease was correlated with iNPH incidence, it may not be a prognostic factor for shunt operation. These findings have implications for the use of dopaminergic imaging, as they might help predict the surgical outcome of patients with iNPH, while vascular mechanisms seem to be involved in iNPH pathophysiology.
- Subjects :
- medicine.medical_specialty
normal pressure hydrocephalus
small vessel disease
lcsh:Medicine
Single Center
Article
030218 nuclear medicine & medical imaging
White matter
03 medical and health sciences
0302 clinical medicine
Normal pressure hydrocephalus
Internal medicine
Medicine
business.industry
lcsh:R
Dopaminergic
Retrospective cohort study
General Medicine
medicine.disease
Comorbidity
Pathophysiology
shunt
Shunt (medical)
dopaminergic degeneration
medicine.anatomical_structure
Cardiology
outcome
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20770383
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....b5af45f046eda17ef39503bbcfb024b7
- Full Text :
- https://doi.org/10.3390/jcm9041084