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Targeting senescence as an anticancer therapy
- Source :
- Molecular Oncology. 16:3855-3880
- Publication Year :
- 2022
- Publisher :
- Wiley, 2022.
-
Abstract
- Cellular senescence is a stress response elicited by different molecular insults. Senescence results in cell cycle exit and is characterised by multiple phenotypic changes such as the production of a bioactive secretome. Senescent cells accumulate during ageing and are present in cancerous and fibrotic lesions. Drugs that selectively kill senescent cells (senolytics) have shown great promise for the treatment of age-related diseases. Senescence plays paradoxical roles in cancer. Induction of senescence limits cancer progression and contributes to therapy success, but lingering senescent cells fuel progression, recurrence, and metastasis. In this review, we describe the intricate relation between senescence and cancer. Moreover, we enumerate how current anti-cancer therapies induce senescence in tumour cells and how senolytic agents could be deployed to complement anticancer therapies. "One-two punch" therapies aim to first induce senescence in the tumour followed by senolytic treatment to target newly exposed vulnerabilities in senescent tumour cells. "One-two punch" represents an emerging and promising new strategy in cancer treatment. Future challenges of "one -two punch" approaches include how to best monitor senescence in cancer patients to effectively survey their efficacy.
- Subjects :
- Aging
oncogene-induced senescence (OIS)
Cancer Research
TUMOR-CELLS
SECRETORY PHENOTYPE
Antineoplastic Agents
chemotherapy
Cellular senescence
Neoplasms
ONCOGENE-INDUCED SENESCENCE
Genetics
Humans
TERMINAL PROLIFERATION ARREST
1112 Oncology and Carcinogenesis
Oncology & Carcinogenesis
radiotherapy
Science & Technology
INDUCED PREMATURE SENESCENCE
BREAST-CANCER CELLS
therapy-induced senescence (TIS)
General Medicine
DNA-DAMAGE
Oncology
senolytics
therapy-induced senescence
Molecular Medicine
ACCELERATED SENESCENCE
Life Sciences & Biomedicine
GROWTH ARREST
Subjects
Details
- ISSN :
- 18780261 and 15747891
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Molecular Oncology
- Accession number :
- edsair.doi.dedup.....b5a587af44527b37104f1a033d661244