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Lung recurrence and its therapeutic strategy in patients with pancreatic cancer
- Source :
- Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. 20(1)
- Publication Year :
- 2019
-
Abstract
- Background /Objectives: The lung is a major metastatic site of pancreatic cancer (PC). We aimed to assess the features and prognosis of patients with PC according to the recurrence pattern and the effect of resection of recurrent lung lesion. Methods We enrolled 168 PC patients who had undergone macroscopically curative resection. All resected lung tumors were evaluated immunohistochemically for expressions of thyroid transcription factor-1 (TTF-1) and napsin A. Results The most common site of first recurrence was the liver and local site, followed by the lung, peritoneum, and lymph node. Lung recurrence was observed significantly later than was liver recurrence. The median survival time (MST) after recurrence in patients with first recurrence in the lung was significantly longer than MST in patients with first recurrence in the liver (15.2 months vs 5.2 months, p = 0.039). Seven patients with lung recurrence underwent resection of the recurrent lesion. Surgical resection of single metastasis limited to the lung showed favorable overall survival after recurrence (MST = 36.5 months). Patients with single metastasis limited to the lung showed significantly lower value of FDG-PET SUVmax of the primary pancreatic tumor. Conclusions Patients with first recurrence in the lung showed better prognosis than did patients with first recurrence in the liver. Single metastasis limited to the lung could benefit from surgical resection and was significantly associated with lower FDG-PET SUVmax of the primary pancreatic tumor.
- Subjects :
- Male
medicine.medical_specialty
Lung Neoplasms
Endocrinology, Diabetes and Metabolism
Gastroenterology
Metastasis
03 medical and health sciences
0302 clinical medicine
Peritoneum
Pancreatic tumor
Recurrence
Pancreatic cancer
Internal medicine
Medicine
Humans
In patient
Lymph node
Aged
Lung
Hepatology
business.industry
Thyroid
respiratory system
Middle Aged
medicine.disease
Pancreatic Neoplasms
medicine.anatomical_structure
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
Female
business
Subjects
Details
- ISSN :
- 14243911
- Volume :
- 20
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
- Accession number :
- edsair.doi.dedup.....b5a205b047e33e3f8ed808a56bc2837d