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Upon microbial challenge, human neutrophils undergo rapid changes in nuclear architecture and chromatin folding to orchestrate an immediate inflammatory gene program
- Source :
- Genes Dev
- Publication Year :
- 2020
- Publisher :
- Cold Spring Harbor Laboratory, 2020.
-
Abstract
- Differentiating neutrophils undergo large-scale changes in nuclear morphology. How such alterations in structure are established and modulated upon exposure to microbial agents is largely unknown. Here, we found that prior to encounter with bacteria, an armamentarium of inflammatory genes was positioned in a transcriptionally passive environment suppressing premature transcriptional activation. Upon microbial exposure, however, human neutrophils rapidly (
- Subjects :
- Transcriptional Activation
Neutrophils
Biology
Proinflammatory cytokine
Histones
03 medical and health sciences
0302 clinical medicine
Gene expression
Escherichia coli
Genetics
CEBPB
Humans
Compartment (development)
Enhancer
Cells, Cultured
Escherichia coli Infections
030304 developmental biology
Cell Nucleus
0303 health sciences
Cohesin
FOSL2
Chromatin
Cell biology
030220 oncology & carcinogenesis
Research Paper
Developmental Biology
Subjects
Details
- ISSN :
- 15495477 and 08909369
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Genes & Development
- Accession number :
- edsair.doi.dedup.....b593c4cf545f52b5f6c08f2e92d76730