Back to Search
Start Over
Structural Transition and Antibody Binding of EBOV GP and ZIKV E Proteins from Pre-Fusion to Fusion-Initiation State
- Source :
- Biomolecules; Volume 8; Issue 2; Pages: 25, Biomolecules, Vol 8, Iss 2, p 25 (2018), Biomolecules
- Publication Year :
- 2018
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2018.
-
Abstract
- Membrane fusion proteins are responsible for viral entry into host cells—a crucial first step in viral infection. These proteins undergo large conformational changes from pre-fusion to fusion-initiation structures, and, despite differences in viral genomes and disease etiology, many fusion proteins are arranged as trimers. Structural information for both pre-fusion and fusion-initiation states is critical for understanding virus neutralization by the host immune system. In the case of Ebola virus glycoprotein (EBOV GP) and Zika virus envelope protein (ZIKV E), pre-fusion state structures have been identified experimentally, but only partial structures of fusion-initiation states have been described. While the fusion-initiation structure is in an energetically unfavorable state that is difficult to solve experimentally, the existing structural information combined with computational approaches enabled the modeling of fusion-initiation state structures of both proteins. These structural models provide an improved understanding of four different neutralizing antibodies in the prevention of viral host entry.
- Subjects :
- 0301 basic medicine
viruses
pre-fusion-to-fusion transition
030106 microbiology
lcsh:QR1-502
Molecular Dynamics Simulation
Antibodies, Viral
medicine.disease_cause
Biochemistry
Article
lcsh:Microbiology
Zika virus
03 medical and health sciences
Immune system
Viral Envelope Proteins
Viral entry
medicine
ZIKV E
EBOV GP
Molecular Biology
chemistry.chemical_classification
Ebola virus
biology
Lipid bilayer fusion
Zika Virus
Virus Internalization
Ebolavirus
biology.organism_classification
Fusion protein
Virology
030104 developmental biology
chemistry
antibody binding
biology.protein
Antibody
Glycoprotein
Protein Binding
Subjects
Details
- Language :
- English
- ISSN :
- 2218273X
- Database :
- OpenAIRE
- Journal :
- Biomolecules; Volume 8; Issue 2; Pages: 25
- Accession number :
- edsair.doi.dedup.....b569ac5994ddc2924ba9d2a3c794ec16
- Full Text :
- https://doi.org/10.3390/biom8020025