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Swallowing induces sequential activation of esophageal longitudinal smooth muscle
- Source :
- Scopus-Elsevier
-
Abstract
- We examined the mechanical activity of the longitudinal and circular muscles of the esophagus at three different levels (9, 5, and 1 cm above the lower esophageal sphincter) during peristalsis induced by swallows or vagal stimulation in anesthetized opossums with miniature strain gauges applied in the axis of muscle fibers. The onset of longitudinal muscle contraction occurred in an aboral sequence with swallows but simultaneously with vagal stimulation. The speed of longitudinal muscle activation with swallows was 7.6 +/- 1.7 cm/s. Circular muscle contraction occurred in an aboral sequence with vagal stimulation and swallowing with speeds of 4.1 +/- 0.8 and 2.3 +/- 0.1 cm/s, respectively. Longitudinal muscle contracted before the circular muscle at all sites. The duration of longitudinal muscle contraction increased aborally (P less than 0.05) with swallowing or vagal stimulation. These studies show that 1) during swallowing, esophageal longitudinal and circular smooth muscle contract in a sequential fashion, 2) the longitudinal muscle sequential contraction is due to central mechanisms, whereas circular muscle sequential contraction may be due to both central and peripheral mechanisms, and 3) peripheral neuromuscular mechanisms produce regional differences in the duration of longitudinal muscle contraction.
- Subjects :
- Male
Contraction (grammar)
Physiology
Manometry
Electromyography
Biology
Esophagus
Swallowing
Physiology (medical)
medicine
Reaction Time
Animals
Peristalsis
Hepatology
medicine.diagnostic_test
digestive, oral, and skin physiology
Gastroenterology
Muscle, Smooth
Vagus Nerve
Anatomy
Opossums
Electric Stimulation
Vagus nerve
Deglutition
Electrophysiology
medicine.anatomical_structure
Female
medicine.symptom
Muscle contraction
Muscle Contraction
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier
- Accession number :
- edsair.doi.dedup.....b5694c2bc4cd7faa1a2442fb9e84e60c