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Associations between plasma neurofilament light, in vivo brain pathology, and cognition in non‐demented individuals with autosomal‐dominant Alzheimer's disease
- Source :
- Alzheimers Dement
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Background Neurofilament light (NfL) is a promising biomarker of early neurodegeneration in Alzheimer's disease (AD). We examined whether plasma NfL was associated with in vivo amyloid beta and tau, and cognitive performance in non-demented presenilin-1 (PSEN1) E280A mutation carriers. Methods Twenty-five mutation carriers and 19 non-carriers (age range: 28 to 49 years) were included in this study. Participants underwent 11C Pittsburgh compound B (PiB)-PET (positron emission tomography), flortaucipir-PET, blood sampling, and cognitive testing. Results Mutation carriers exhibited higher plasma NfL levels than non-carriers. In carriers, higher NfL levels were related to greater regional tau burden and worse cognition, but not amyloid beta load. When we adjusted for age, a proxy of disease progression, elevated plasma NfL levels were only correlated with worse memory recall. Conclusions Findings support an association between plasma NfL, cognition, and tau pathology in non-demented individuals at genetic risk for developing AD dementia. Plasma NfL may be useful for selecting individuals at increased risk and tracking disease progression in AD.
- Subjects :
- Male
0301 basic medicine
Oncology
Epidemiology
Disease
Neuropsychological Tests
chemistry.chemical_compound
0302 clinical medicine
Neurofilament Proteins
PSEN1
biology
Health Policy
Brain
Healthy Volunteers
Psychiatry and Mental health
Biomarker (medicine)
Female
Adult
medicine.medical_specialty
Genotype
Amyloid beta
Prodromal Symptoms
tau Proteins
Article
Presenilin
03 medical and health sciences
Cellular and Molecular Neuroscience
Developmental Neuroscience
Alzheimer Disease
Internal medicine
Presenilin-1
medicine
Humans
Dementia
Genetic Predisposition to Disease
Amyloid beta-Peptides
business.industry
medicine.disease
Cross-Sectional Studies
030104 developmental biology
chemistry
Positron-Emission Tomography
Mutation
biology.protein
Neurology (clinical)
Geriatrics and Gerontology
Pittsburgh compound B
business
Biomarkers
030217 neurology & neurosurgery
Blood sampling
Subjects
Details
- ISSN :
- 15525279 and 15525260
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Alzheimer's & Dementia
- Accession number :
- edsair.doi.dedup.....b55b88999f05e47e4b78e09085081dca