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Examining the Association of Socioeconomic Position with Microcephaly and Delayed Childhood Neurodevelopment among Children with Prenatal Zika Virus Exposure
- Source :
- Viruses, Vol 12, Iss 1342, p 1342 (2020), Viruses, Volume 12, Issue 11
- Publication Year :
- 2020
- Publisher :
- MDPI, 2020.
-
Abstract
- Increased rates of Zika virus have been identified in economically deprived areas in Brazil at the population level<br />yet, the implications of the interaction between socioeconomic position and prenatal Zika virus exposure on adverse neurodevelopmental outcomes remains insufficiently evaluated at the individual level. Using data collected between September 2015 and September 2019 from 163 children with qRT-PCR and/or IgM-confirmed prenatal exposure to Zika virus participating in a prospective cohort study in Rio de Janeiro, Brazil (NCT03255369), this study evaluated the relationships of socioeconomic indicators with microcephaly at birth and Bayley-III neurodevelopmental scores during the early life course. Adjusted logistic regression models indicated increased odds of microcephaly in children born to families with lower household income (OR, 95% CI: 3.85, 1.43 to 10.37) and higher household crowding (OR, 95% CI: 1.83, 1.16 to 2.91), while maternal secondary and higher education appeared to have a protective effect for microcephaly compared to primary education (OR, 95% CI: 0.33, 0.11 to 0.98 and 0.10, 0.03 to 0.36, respectively). Consistent with these findings, adjusted linear regression models indicated lower composite language (&minus<br />10.78, 95% CI: &minus<br />19.87 to &minus<br />1.69), motor (&minus<br />10.45, 95% CI: &minus<br />19.22 to &minus<br />1.69), and cognitive (&minus<br />17.20, 95% CI: &minus<br />26.13 to &minus<br />8.28) scores in children whose families participated in the Bolsa Fam&iacute<br />lia social protection programme. As such, the results from this investigation further emphasise the detrimental effects of childhood disadvantage on human health and development by providing novel evidence on the link between individual level socioeconomic indicators and microcephaly and delayed early life neurodevelopment following prenatal Zika virus exposure.
- Subjects :
- Adult
Male
Microcephaly
congenital Zika syndrome
Adolescent
viruses
030231 tropical medicine
lcsh:QR1-502
Mothers
Logistic regression
Article
lcsh:Microbiology
Zika virus
03 medical and health sciences
Young Adult
0302 clinical medicine
Pregnancy
Virology
parasitic diseases
Medicine
Humans
030212 general & internal medicine
Prospective Studies
microcephaly
Pregnancy Complications, Infectious
Prospective cohort study
Socioeconomic status
health equity
biology
neurodevelopment
business.industry
Zika Virus Infection
Infant
socioeconomic position
medicine.disease
biology.organism_classification
Crowding
Health equity
Infectious Diseases
Socioeconomic Factors
Neurodevelopmental Disorders
Child, Preschool
Prenatal Exposure Delayed Effects
Household income
Female
business
Brazil
Demography
Subjects
Details
- Language :
- English
- ISSN :
- 19994915
- Database :
- OpenAIRE
- Journal :
- Viruses, Vol 12, Iss 1342, p 1342 (2020), Viruses, Volume 12, Issue 11
- Accession number :
- edsair.doi.dedup.....b55645b02675f046b45f47226f5ec438