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Propafenone treatment of recurrent ventricular tachycardia: comparison of continuous electrocardiographic recording and electrophysiologic study in predicting drug efficacy
- Source :
- The American journal of cardiology. 54(9)
- Publication Year :
- 1984
-
Abstract
- Propafenone was administered to 29 patients who had multiple episodes of recurrent ventricular tachycardia (VT) or ventricular fibrillation (VF) despite previous antiarrhythmic therapy. All patients had 24-hour continuous electrocardiographic recording and electrophysiologic study in a drug-free control state and while receiving maximum doses of propafenone. During propafenone treatment, the mean frequency of ventricular premature complexes (VPCs) decreased 74% (p less than 0.05). There was more than an 83% decrease in VPC frequency in 17 of 29 patients, and 11 patients had 99 to 100% decreases. Propafenone prevented VT induction at electrophysiologic study in 6 patients, whereas another 12 patients were judged to have satisfactory electrophysiologic responses on the basis of slower VT rates and absence of hemodynamic compromise during VT. After long-term treatment from 2 to 26 months, 9 patients continued propafenone without evidence of recurrent arrhythmia. Six of these 9 patients had not VT induction at electrophysiologic study while receiving propafenone. The decrease in VPC frequency produced by propafenone was a poor predictor of a successful electrophysiologic study and of long-term therapy. In conclusion, propafenone has potential as an effective antiarrhythmic agent, but better methods to stratify risk for recurrence of VT and VF are needed.
- Subjects :
- Adult
Male
medicine.medical_specialty
Ventricular Premature Complexes
Propafenone
Efficacy
Electrocardiography
Recurrence
Internal medicine
Tachycardia
Electrophysiologic study
Medicine
Humans
cardiovascular diseases
Aged
Propiophenones
medicine.diagnostic_test
business.industry
Recurrent ventricular tachycardia
Cardiac Pacing, Artificial
Middle Aged
Mean frequency
medicine.disease
Anesthesia
Ventricular fibrillation
Ventricular Fibrillation
cardiovascular system
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Anti-Arrhythmia Agents
medicine.drug
Subjects
Details
- ISSN :
- 00029149
- Volume :
- 54
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- The American journal of cardiology
- Accession number :
- edsair.doi.dedup.....b555e20bbd339d4bbca1acf580e76917