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Correlation of genotypes for thiopurine methyltransferase and inosine triphosphate pyrophosphatase with long-term clinical outcomes in Korean patients with inflammatory bowel diseases during treatment with thiopurine drugs
- Source :
- Journal of Human Genetics. 55:121-123
- Publication Year :
- 2009
- Publisher :
- Springer Science and Business Media LLC, 2009.
-
Abstract
- There is a lack of research describing the associations between thiopurine methyltransferase (TPMT)/inosine triphosphate pyrophosphatase (ITPA) genotypes and long-term clinical outcomes. We investigated whether TPMT/ITPA genotypes predicted long-term clinical response in Korean patients with inflammatory bowel diseases (IBDs) undergoing thiopurine treatment. A total of 204 patients with IBD in whom thiopurine treatment was indicated were enrolled and categorized by TPMT and ITPA genotypes. Long-term follow-up clinical data for these patients were analyzed with specific focus on disease relapse. Of the 204 patients, 162 (79.4%) patients using thiopurines achieved remission and were included in an analysis of long-term clinical outcomes. There were no significant differences in disease relapse-free survival between wild and mutant types of TPMT (P=0.903) or ITPA (P=0.392), according to the results of the log-rank analysis. Our study suggests that TPMT and ITPA genotypes may not affect the rates of disease relapse in IBD patients treated with thiopurines. Further studies are indicated to confirm the utility of TPMT/ITPA genotyping to guide clinicians formulating individualized treatments for IBD patients requiring thiopurine therapy.
- Subjects :
- medicine.medical_specialty
Genotype
Azathioprine
Disease
Pharmacology
Gastroenterology
Inflammatory bowel disease
Asian People
Gene Frequency
Recurrence
Internal medicine
Genetics
medicine
Humans
Pyrophosphatases
Genotyping
Genetics (clinical)
Thiopurine methyltransferase
biology
Mercaptopurine
business.industry
Inflammatory Bowel Diseases
Methyltransferases
medicine.disease
Treatment Outcome
biology.protein
ITPA
business
medicine.drug
Subjects
Details
- ISSN :
- 1435232X and 14345161
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Journal of Human Genetics
- Accession number :
- edsair.doi.dedup.....b54b4967eedffe5b5f27abd7970d1b9a