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Euthymic bipolar disorder patients and EEG microstates: a neural signature of their abnormal self experience?
- Source :
- Journal of Affective Disorders. 272:326-334
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Background: A growing number of neuroimaging studies have revealed spatial abnormalities of resting-state functional brain network activity in bipolar disorder (BD). Conversely, abnormalities of resting state temporal dynamics have been scarcely investigated so far. The aim of this study was to characterize the EEG microstates activity in BD patients with a history of manic predominant polarity. Patients were euthymic and pharmacologically stabilized. Methods: Nineteen BD patients (mean age 34.4 ± 11.0, 7 female) and 19 healthy controls (HC; mean age 38.2 ± 9.9, 7 female) were recruited. The psychometric evaluation included the Hamilton Depression Scale (HAMD), the Young Mania Rating Scale (YMRS), the Dissociative Experience Scale (DES), and the State-Trait Anxiety Inventory (STAI). Two runs of 2 minutes of EEG activity by a 128-channel system were acquired at rest and analyzed through microstate analysis. Results: We found a reduced presence of microstate B in BD patients compared to HC, since BD patients have a tendency to transit from the microstate B to the microstates C and D significantly more than HC. Furthermore, microstate B features were correlated with DES, state STAI and trait STAI scores. Conclusion: The reduced presence of microstate B might be associated with episodic autobiographic memory deficit, exaggerated self-focusing and states of dissociations characteristic of BD. Strong correlations of microstate B metrics and dynamics with symptoms of dissociation and anxiety across the two groups supported this interpretation.
- Subjects :
- Adult
medicine.medical_specialty
Bipolar Disorder
medicine.drug_class
Neuroimaging
Audiology
Dissociative
Young Mania Rating Scale
Young Adult
03 medical and health sciences
0302 clinical medicine
Ministate
Hamd
medicine
Humans
Bipolar disorder
Resting state fMRI
business.industry
Brain
Electroencephalography
Middle Aged
medicine.disease
Cyclothymic Disorder
030227 psychiatry
Psychiatry and Mental health
Clinical Psychology
EEG microstates
Anxiety
Female
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 01650327
- Volume :
- 272
- Database :
- OpenAIRE
- Journal :
- Journal of Affective Disorders
- Accession number :
- edsair.doi.dedup.....b5336658b1316c32bc954b3bcbd45c57