Design and Synthesis of a 2-Amino-pyridine Derivative as a Potent CDK8 Inhibitor for Anti-colorectal Cancer Therapy

Authors :: Yao Yao, Yan
Xing Xing, Zhang
Yun, Xiao
Xiao Bao, Shen
Yu Jie, Jian
Yu Meng, Wang
Zi Hao, She
Ming Ming, Liu
Xin Hua, Liu
Source :: Journal of Medicinal Chemistry. 65:13216-13239
Publication Year :: 2022
Publisher :: American Chemical Society (ACS), 2022.
Abstract: CDK8 is a transcriptional cyclin-dependent kinase and considered as a potential target in colon cancer therapeutics. Here, a novel selective CDK8 inhibitor was identified against colon cancer

Subjects :: Cell Line, Tumor
Colonic Neoplasms
Drug Discovery
Humans
Molecular Medicine
Sorafenib
Cyclin-Dependent Kinase 8
Protein Kinase Inhibitors
Cyclin-Dependent Kinases
beta Catenin

Tools