Thalassemias

Authors :: Alissa, Martin
Alexis A, Thompson
Source :: Pediatric Clinics of North America. 60:1383-1391
Publication Year :: 2013
Publisher :: Elsevier BV, 2013.
Abstract: The thalassemia syndromes are hemoglobin disorders that result from significantly reduced or absent synthesis of either the α- or β-globin chains. The result is a chronic hemolytic anemia with ineffective erythropoiesis and bone marrow overstimulation. This article reviews current diagnostic approaches, complications, and disease management of thalassemia.