Back to Search
Start Over
Circulating tumor cells before and during follow-up after breast cancer surgery
- Source :
- International journal of oncology, 46(1), 407-413. Spandidos Publications
- Publication Year :
- 2014
-
Abstract
- The presence of circulating tumor cells (CTC) is an independent prognostic factor for progression-free and overall survival for patients with metastatic and newly diagnosed breast cancer. The present study was undertaken to explore whether the presence of CTC before and during follow-up after surgery is associated with recurrence free survival (RFS) and overall survival (OS). In a prospective single center study, CTC were enumerated with the CellSearch system in 30 ml of peripheral blood of 403 stage I-III patients before undergoing surgery for breast cancer (A) and if available 1 week after surgery (B), after adjuvant chemo- and/or radiotherapy or before start of long-term hormonal therapy (C), one (D), two (E) and three (F) years after surgery. Patients were stratified into unfavorable (CTC ≥1) and favorable (CTC=0) prognostic groups. >1 CTC in 30 ml blood was detected in 75/403 (19%) at A, 66/367 (18%) at B, 40/263 (15%) at C, 30/235 (12%) at D, 18/144 (11%) at E and 11/83 (13%) at F. RFS and OS was significantly lower for unfavorable CTC as compared to favorable CTC before surgery (p=0.022 and p=0.006), after adjuvant therapy (p
- Subjects :
- Adult
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
Breast Neoplasms
Circulating tumor cell
Breast cancer
Recurrence
Adjuvant therapy
Biomarkers, Tumor
Medicine
Humans
Survival analysis
Mastectomy
Aged
Aged, 80 and over
business.industry
Cancer
Middle Aged
medicine.disease
Neoplastic Cells, Circulating
Prognosis
Survival Analysis
n/a OA procedure
Surgery
Radiation therapy
Treatment Outcome
Oncology
Hormonal therapy
Female
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 17912423 and 10196439
- Volume :
- 46
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- International journal of oncology
- Accession number :
- edsair.doi.dedup.....b51facd412ac3d65115b598accc5fd35