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Mimicking the human smell sensing mechanism with an artificial nose platform
- Source :
- Biomaterials. 33:1722-1729
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Sensing smell is a highly complex biological process, and characterizing and mimicking the interaction between the olfactory receptor (OR) protein and its ligands is extremely challenging. Herein, we report a highly sensitive and selective human nose-like nanobioelectronic nose (nbe-nose), which responds to gaseous odorants sensitively and selectively, has a signal specificity pattern similar to that in the cellular signal transduction pathway, and maintains an antagonistic behavior similar to the human nose. The human olfaction mechanism was mimicked by using carboxylated polypyrrole nanotubes (CPNTs) functionalized with human OR protein. The nbe-nose was able to detect gaseous odorants at a concentration as low as 0.02 parts-per-trillion (ppt), which was comparable to a highly trained, human expert's nose. The nbe-nose can be used scientifically for smell mechanism studies. It can be also applied to various fields that rely on smell monitoring for industrial and public purposes.
- Subjects :
- Olfactory system
Sensation
Biophysics
Bioengineering
Nanotechnology
Olfaction
Nose
Biology
Ligands
Receptors, Odorant
Cell Line
Biomaterials
Human nose
otorhinolaryngologic diseases
medicine
Humans
Pyrroles
Electrodes
Nanotubes
Olfactory receptor
Mechanism (biology)
Equipment Design
Olfactory Pathways
Cellular signal transduction
Protein Structure, Tertiary
Highly sensitive
Electrophysiology
Smell
medicine.anatomical_structure
Mechanics of Materials
Odorants
Ceramics and Composites
Gases
Artificial nose
Biotechnology
Signal Transduction
Subjects
Details
- ISSN :
- 01429612
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Biomaterials
- Accession number :
- edsair.doi.dedup.....b504d6ee7c1018109d6aef96128a7029