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Major Adverse Events Associated With Treatment of Infantile Spasms
- Source :
- Journal of Child Neurology. 22:1360-1366
- Publication Year :
- 2007
- Publisher :
- SAGE Publications, 2007.
-
Abstract
- Few studies have focused on tolerability and adverse events associated with natural adrenocorticotropic hormone injections for treatment of infantile spasms. Using a retrospective chart review of 130 patients, the authors compare major adverse events, weight and blood pressure changes, and unplanned medication changes associated with adrenocorticotropic hormone (ACTH) injections versus other antiepileptic drugs. Children treated with adrenocorticotropic hormone injections experienced significant short-term weight gain and blood pressure elevations, which were readily reversible with weaning off the drug. Twenty-three percent of patients treated with adrenocorticotropic hormone (14 of 60) and 17% of patients treated with other antiepileptic drugs (11 of 65) experienced a major adverse event during treatment. Few patients overall required a change in medication due to intolerable side effects. Despite early changes in weight and blood pressure, short courses of high-dose natural adrenocorticotropic hormone are generally well tolerated with no increased major adverse events when compared to antiepileptic drugs in the treatment of infantile spasms.
- Subjects :
- Male
Drug
media_common.quotation_subject
Blood Pressure
Adrenocorticotropic hormone
Weight Gain
03 medical and health sciences
0302 clinical medicine
Adrenocorticotropic Hormone
030225 pediatrics
medicine
Humans
Weaning
Adverse effect
Retrospective Studies
media_common
business.industry
Infant
Retrospective cohort study
Hormones
Treatment Outcome
Blood pressure
Tolerability
Anesthesia
Injections, Intravenous
Pediatrics, Perinatology and Child Health
Anticonvulsants
Female
Neurology (clinical)
medicine.symptom
business
Spasms, Infantile
Weight gain
030217 neurology & neurosurgery
Follow-Up Studies
Subjects
Details
- ISSN :
- 17088283 and 08830738
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Journal of Child Neurology
- Accession number :
- edsair.doi.dedup.....b50182c6ca584458b49928bd81172877