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Inhibitory control dysfunction in parkinsonian impulse control disorders
- Source :
- Brain-A Journal of Neurology, Brain-A Journal of Neurology, Oxford University Press (OUP), 2021, 143, pp.3734-3747. ⟨10.1093/brain/awaa318⟩
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- Impulse control disorders (ICDs) in Parkinson’s disease have been associated with dysfunctions in the control of value- or reward-based responding (choice impulsivity) and abnormalities in mesocorticolimbic circuits. The hypothesis that dysfunctions in the control of response inhibition (action impulsivity) also play a role in Parkinson’s disease ICDs has recently been raised, but the underlying neural mechanisms have not been probed directly. We used high-resolution EEG recordings from 41 patients with Parkinson’s disease with and without ICDs to track the spectral and dynamical signatures of different mechanisms involved in inhibitory control in a simple visuomotor task involving no selection between competing responses and no reward to avoid potential confounds with reward-based decision. Behaviourally, patients with Parkinson’s disease with ICDs proved to be more impulsive than those without ICDs. This was associated with decreased beta activity in the precuneus and in a region of the medial frontal cortex centred on the supplementary motor area. The underlying dynamical patterns pinpointed dysfunction of proactive inhibitory control, an executive mechanism intended to gate motor responses in anticipation of stimulation in uncertain contexts. The alteration of the cortical drive of proactive response inhibition in Parkinson’s disease ICDs pinpoints the neglected role the precuneus might play in higher order executive functions in coordination with the supplementary motor area, specifically for switching between executive settings. Clinical perspectives are discussed in the light of the non-dopaminergic basis of this function.
- Subjects :
- Male
Impulse control disorder
Precuneus
impulsivity
Neuropsychological Tests
Electroencephalography
Impulsivity
Choice Behavior
050105 experimental psychology
Executive Function
03 medical and health sciences
precuneus
0302 clinical medicine
Parkinsonian Disorders
Dopamine
Parietal Lobe
medicine
Humans
0501 psychology and cognitive sciences
Parkinson
Aged
Brain Mapping
Supplementary motor area
medicine.diagnostic_test
business.industry
05 social sciences
Middle Aged
medicine.disease
Executive functions
Anticipation
Disruptive, Impulse Control, and Conduct Disorders
inhibitory control
Inhibition, Psychological
medicine.anatomical_structure
Impulsive Behavior
Female
beta
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Neurology (clinical)
Nerve Net
medicine.symptom
Beta Rhythm
business
Neuroscience
Psychomotor Performance
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 14602156 and 00068950
- Volume :
- 143
- Database :
- OpenAIRE
- Journal :
- Brain
- Accession number :
- edsair.doi.dedup.....b4efe6c88c5ed9ae5d990acc7ef37e38