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Identification and Validation of Protein Biomarkers of Response to Neoadjuvant Platinum Chemotherapy in Muscle Invasive Urothelial Carcinoma
- Source :
- PLoS ONE, PLoS ONE, Vol 10, Iss 7, p e0131245 (2015)
- Publication Year :
- 2015
-
Abstract
- Background The 5-year cancer specific survival (CSS) for patients with muscle invasive urothelial carcinoma of the bladder (MIBC) treated with cystectomy alone is approximately 50%. Platinum based neoadjuvant chemotherapy (NAC) plus cystectomy results in a marginal 5-10% increase in 5-year CSS in MIBC. Interestingly, responders to NAC (
- Subjects :
- Oncology
medicine.medical_specialty
Pathology
Multidisciplinary
Bladder cancer
Tissue microarray
medicine.diagnostic_test
business.industry
medicine.medical_treatment
lcsh:R
lcsh:Medicine
medicine.disease
Cystectomy
Internal medicine
Biopsy
Cohort
medicine
Carcinoma
Immunohistochemistry
lcsh:Q
lcsh:Science
business
Neoadjuvant therapy
Research Article
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, PLoS ONE, Vol 10, Iss 7, p e0131245 (2015)
- Accession number :
- edsair.doi.dedup.....b4dcaaf83802b7173c95fa743d882248