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Effect of Polydextrose/Fructooligosaccharide Mixture on Constipation Symptoms in Children Aged 4 to 8 Years
- Source :
- Nutrients, Vol 13, Iss 1634, p 1634 (2021), Nutrients, Volume 13, Issue 5
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Constipation is a frequent problem in children. We evaluated the effect of a mixture (polydextrose [PDX] and fructooligosaccharide [FOS]) in children with constipation. We performed a prospective interventional study with a mixture (PDX 4.17 g and FOS 0.45 g) in a daily dose of food supplement. The intervention lasted 45 days, with visits at 15, 30, and 45 days after administration. The sample comprised 105 patients, of whom 77 completed the intervention. A statistically significant reduction in the frequency of symptoms was observed at the end of the study. The frequency of children with fewer than three bowel movements per week dropped from 59.7% to 11.7%, and there was a decrease in the frequency of Bristol type 1 and 2 dry stools (68.8% to 7.8%), pain on defecation (79.2% to 10.4%), and fear of defecation (68.8% to 3.9%). The proportion of children with abdominal pain symptoms decreased from 84.2% to 2.6% at the end of the study. A relevant limitation of the present study was the lack of a control group treated with placebo. The administration of the PDX/FOS mixture was accompanied by a significant reduction in the frequency of constipation symptoms of the children evaluated. The tolerability was very good, and the rate of adverse effects was low.
- Subjects :
- Male
medicine.medical_specialty
Abdominal pain
Constipation
Oligosaccharides
Placebo
Gastroenterology
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
Humans
TX341-641
030212 general & internal medicine
Adverse effect
Child
Glucans
Nutrition and Dietetics
Polydextrose
business.industry
Nutrition. Foods and food supply
Fructooligosaccharide
clinical trial
constipation
dietary fiber
Tolerability
chemistry
Child, Preschool
Dietary Supplements
Defecation
030211 gastroenterology & hepatology
Drug Therapy, Combination
Female
medicine.symptom
business
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Volume :
- 13
- Issue :
- 1634
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....b4c815c2afbd1c612aa42ab22373e101