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EBV positive primary cutaneous CD30+ large T-cell lymphoma in a heart transplanted patient: case report
- Source :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 4(11)
- Publication Year :
- 2004
-
Abstract
- Most post-transplant lymphoproliferative disorders (PTLDs) are of B-cell origin, whereas T-cell lymphomas rarely occur. We detail the clinicopathological features of the first case of Epstein-Barr virus (EBV)-associated primary cutaneous CD30+ anaplastic large cell lymphoma (ALCL) in the setting of heart transplant. A 71-year-old patient, 111 months after transplant, presented with multiple cutaneous lesions on the left thigh; histological and immunohistochemical examinations led to diagnosis of T-cell CD30+ ALCL. In situ hybridization demonstrated the presence of EBV-positive tumour cells. The patient received radiotherapy, but he relapsed at the same cutaneous site with loco-regional nodal spread. Chemotherapy was administered resulting in complete remission; four years later the patient is alive and well. Our findings indicate that primary cutaneous EBV+ CD30+ ALCLs should be included within the T-cell PTLDs spectrum; further studies are required to confirm whether they may be also considered, in transplantation settings, a distinct lymphoma subset with relatively favourable outcome.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Herpesvirus 4, Human
Skin Neoplasms
CD30
medicine.medical_treatment
Lymphoproliferative disorders
Ki-1 Antigen
Antineoplastic Agents
Postoperative Complications
Antigens, CD
hemic and lymphatic diseases
HIV Seropositivity
medicine
Immunology and Allergy
Humans
Pharmacology (medical)
Anaplastic large-cell lymphoma
Aged
Transplantation
Chemotherapy
business.industry
medicine.disease
Immunohistochemistry
Lymphoproliferative Disorders
Lymphoma
Radiation therapy
Treatment Outcome
Cyclosporine
Heart Transplantation
RNA, Viral
Lymphoma, Large B-Cell, Diffuse
business
Subjects
Details
- ISSN :
- 16006135
- Volume :
- 4
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
- Accession number :
- edsair.doi.dedup.....b4c4876f3ce293056ad8c31ed7fafcbb