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Cloning a novel developmental regulating gene, Xotx5: Its potential role in anterior formation in Xenopus laevis
- Source :
- Development, Growth and Differentiation. 42:87-93
- Publication Year :
- 2000
- Publisher :
- Wiley, 2000.
-
Abstract
- The vertebrate Otx gene family is related to otd, a gene contributing to head development in Drosophila. In Xenopus, Xotx1, Xotx2, and Xotx4 have already been isolated and analyzed. Here the cloning, developmental expression and functions of the additional Otx Xenopus gene, Xotx5 are reported. This latter gene shows a greater degree of homology to Xotx2 than Xotx1 and Xotx4. Xotx5 was initially expressed in Spemann's organizer and later in the anterior region. Ectopic expression of Xotx5 had similar effects to other Xotx genes in impairing trunk and tail development, and especially similar effects to Xotx2 in causing secondary cement glands. Taken together, these findings suggest that Xotx5 stimulates the formation of the anterior regions and represses the formation of posterior structures similar to Xotx2.
- Subjects :
- Homeodomain Proteins
Genetics
Base Sequence
biology
Molecular Sequence Data
Xenopus
Gene Expression Regulation, Developmental
Vertebrate
Nerve Tissue Proteins
Cell Biology
Xenopus Proteins
biology.organism_classification
Homology (biology)
Anterior region
Xenopus laevis
biology.animal
Animals
Gene family
Homeobox
Ectopic expression
Amino Acid Sequence
Cloning, Molecular
Gene
Developmental Biology
Subjects
Details
- ISSN :
- 1440169X and 00121592
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Development, Growth and Differentiation
- Accession number :
- edsair.doi.dedup.....b4ac328c3ee5f8a4afcc74393ed002fd