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ESBL expression and antibiotic resistance patterns in a hospital in Saudi Arabia: Do healthcare staff have the whole picture?
- Source :
- Journal of Infection and Public Health, Vol 13, Iss 5, Pp 759-766 (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Background: We analyse the distribution of ESBL infections in Dammam Medical Complex, Eastern Province, Saudi Arabia with respect to patient demographics, wards, infection site, bacterial species, and antibiotic resistance. We also gauged hospital staff understanding of ESBLs, the procedures in place to identify, treat and infections containing. Methods: Hospital records from 2016 were analysed and 352 ESBL from several samples types were identified using VITEK® 2 system and by phenotypic confirmation using a disk diffusion test. HCWs attitudes and knowledge were assessed using a paper questionnaire. Results: The percentage of ESBL isolates were Klebsiella pneumoniae(n = 148; 42.1%) or Escherichia coli(n = 176; 50%), Proteus mirabilis(n = 7; 2%), Morganella morganii(n = 13; 3.7%), Enterobacter (n = 7; 2%) and Citrobacter freundii (n = 1; 0.3%). Overall tigecycline susceptibility was 82.2%, however P. mirabilis and M. morganii isolates were uniformly resistant and K. pneumoniae susceptibility levels were significantly lower than for E. coli in urine samples (72.3% v 100%; Chi square = 13.76, p = 0.0002); for blood samples there was also apparently higher resistance among K. pneumoniae isolates. Overall susceptibility to the carbapenems imipenem, meropenem and ertapenam was high. There were overall high levels of uncertainty among healthcare workers on hospital policies on reporting or prescribing with respect to ESBL-expressing infections. Conclusions: ESBL control strategies should consider variations among sample types, wards, and antibiotic resistance variability. There is a need to specifically address staff training and communication procedures for infection prevention and control with respect to ESBLs. Keywords: ESBL, Saudi Arabia, Enterobacteriaceae, Antibiotic resistance, Healthcare workers
- Subjects :
- Male
0301 basic medicine
Imipenem
Klebsiella pneumoniae
Tigecycline
0302 clinical medicine
Surveys and Questionnaires
polycyclic compounds
Infection control
030212 general & internal medicine
Child
Aged, 80 and over
biology
lcsh:Public aspects of medicine
Enterobacteriaceae Infections
Drug Resistance, Microbial
General Medicine
Middle Aged
Hospitals
Infectious Diseases
Child, Preschool
Female
medicine.drug
Adult
medicine.medical_specialty
Adolescent
Attitude of Health Personnel
Health Personnel
030106 microbiology
Saudi Arabia
Microbial Sensitivity Tests
Meropenem
beta-Lactamases
lcsh:Infectious and parasitic diseases
Young Adult
03 medical and health sciences
Antibiotic resistance
Enterobacteriaceae
Internal medicine
Escherichia coli
medicine
Humans
lcsh:RC109-216
Proteus mirabilis
Aged
business.industry
Infant, Newborn
Public Health, Environmental and Occupational Health
Infant
lcsh:RA1-1270
biochemical phenomena, metabolism, and nutrition
biology.organism_classification
bacterial infections and mycoses
bacteria
Morganella morganii
business
Subjects
Details
- Language :
- English
- ISSN :
- 18760341
- Volume :
- 13
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of Infection and Public Health
- Accession number :
- edsair.doi.dedup.....b4aae21c29cffbd3f071459d15e357b7