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Optimum morphology of gold nanorods for light-induced hyperthermia
- Source :
- UPCommons. Portal del coneixement obert de la UPC, Universitat Politècnica de Catalunya (UPC), Nanoscale, Recercat. Dipósit de la Recerca de Catalunya, instname
- Publication Year :
- 2017
- Publisher :
- Royal Society of Chemistry, 2017.
-
Abstract
- Owing to their unique chemical and physical properties, colloidal gold nanoparticles have prompted a wide variety of biocompatible nano-agents for cancer imaging, diagnosis and treatment. In this context, biofunctionalized gold nanorods (AuNRs) are promising candidates for light-induced hyperthermia, to cause local and selective damage in malignant tissue. Yet, the efficacy of AuNR-based hyperthermia is highly dependent on several experimental parameters; in particular, the AuNR morphology strongly affects both physical and biological involved processes. In the present work, we systematically study the influence of different structural parameters like the AuNR aspect ratio, length and molecular weight on in vitro cytotoxicity, cellular uptake and heat generation efficiency. Our results enable us to identify the optimum AuNR morphology to be used for in vivo hyperthermia treatment.
- Subjects :
- Hyperthermia
Materials science
Morphology (linguistics)
Nanopartícules
Física [Àrees temàtiques de la UPC]
Nanoparticle
Hyperthermia Treatment
Nanotechnology
Context (language use)
02 engineering and technology
010402 general chemistry
021001 nanoscience & nanotechnology
medicine.disease
01 natural sciences
gold nanorods
0104 chemical sciences
Colloidal gold
Heat generation
medicine
Nanoparticles
General Materials Science
Nanorod
0210 nano-technology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- UPCommons. Portal del coneixement obert de la UPC, Universitat Politècnica de Catalunya (UPC), Nanoscale, Recercat. Dipósit de la Recerca de Catalunya, instname
- Accession number :
- edsair.doi.dedup.....b498c928528492b3a36fbd1ae471f7f0