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A Three-State Model for Connexin37 Gating Kinetics

A Three-State Model for Connexin37 Gating Kinetics

Authors :
Elizabeth Peterson
Kulandaiappan Varadaraj
Peter R. Brink
S.V. Ramanan
K. Schirrmacher
K. Banach
Source :
Biophysical Journal. (5):2520-2529
Publisher :
The Biophysical Society. Published by Elsevier Inc.

Abstract

The gating behavior of human connexin 37 (hCx37) is unaffected by the nature of the bathing monovalent (for Na, K, Rb). It is modified by [Mg] in the millimolar range. For fitting the kinetics, we propose a simple extension to three states of the canonical 2-state model of the hemichannel. The extra closed state allows for some immobilization of a hemichannel at high transjunctional voltages. The model is reasonably efficient at fitting data at various voltage protocols. Interpreting the fits of the data at different [Mg] is consistent with a binding site for Mg.

Details

Language :
English
ISSN :
00063495
Issue :
5
Database :
OpenAIRE
Journal :
Biophysical Journal
Accession number :
edsair.doi.dedup.....b4972b7ead1219f3e513507096d97ae4
Full Text :
https://doi.org/10.1016/S0006-3495(99)77406-0