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A Three-State Model for Connexin37 Gating Kinetics
A Three-State Model for Connexin37 Gating Kinetics
- Source :
- Biophysical Journal. (5):2520-2529
- Publisher :
- The Biophysical Society. Published by Elsevier Inc.
-
Abstract
- The gating behavior of human connexin 37 (hCx37) is unaffected by the nature of the bathing monovalent (for Na, K, Rb). It is modified by [Mg] in the millimolar range. For fitting the kinetics, we propose a simple extension to three states of the canonical 2-state model of the hemichannel. The extra closed state allows for some immobilization of a hemichannel at high transjunctional voltages. The model is reasonably efficient at fitting data at various voltage protocols. Interpreting the fits of the data at different [Mg] is consistent with a binding site for Mg.
- Subjects :
- State model
Gating kinetics
Chemistry
Kinetics
Analytical chemistry
Biophysics
Thermodynamics
Gating
In Vitro Techniques
Transfection
Models, Biological
Biophysical Phenomena
Connexins
Recombinant Proteins
Closed state
Electrochemistry
Tumor Cells, Cultured
Humans
Magnesium
Ion Channel Gating
Ion channel gating
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 00063495
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Biophysical Journal
- Accession number :
- edsair.doi.dedup.....b4972b7ead1219f3e513507096d97ae4
- Full Text :
- https://doi.org/10.1016/S0006-3495(99)77406-0