Back to Search
Start Over
Peri-aortic fat tissue and malnutrition–inflammation–atherosclerosis/calcification syndrome in end-stage renal disease patients
- Source :
- International Urology and Nephrology. 45:857-867
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- Thoracic peri-aortic fat tissue (PFT) is considered as a metabolically active organ in atherosclerosis. Malnutrition, inflammation and atherosclerosis/calcification (MIAC) are the most commonly encountered risk factors of cardiovascular disease in end-stage renal disease (ESRD) patients. Calcification of the aorta was found to be an important cardiovascular risk marker predicting future events, morbidity and mortality in this population. We aimed to investigate the relationship between PFT, MIAC syndrome and thoracic aortic calcification (TAC) in ESRD patients.Seventy-nine ESRD patients receiving hemodialysis (HD) or peritoneal dialysis (PD) and 20 control subjects were enrolled in this cross-sectional study. PFT and TAC were assessed using a 64-MDCT scanner. Patients with serum albumin3.5 g/dL were defined as patients with malnutrition; those with serum C-reactive protein level10 mg/L had inflammation, and those with coronary artery calcification score (CACS)10 had atherosclerosis/calcification.TAC and PFT were significantly higher in ESRD patients compared with control subjects. There was a statistically significant relationship between PFT and TAC in ESRD patients (r = 0.458, p0.0001). PFT was found to be significantly increased when the MIAC components increased. PFT was positively associated with age, BMI, uric acid, hemoglobin and CAC. The multivariate analysis revealed that age and uric acid were independent predictors of increased PFT. Twenty-four (30.4 %) patients had none, 30 (37.9 %) had one component, 17 (21.5 %) had two components, and 8 (10.2 %) had all MIAC components. PFT was highest among patients having all three components (28.6 cm(3)) and lowest among those who do not have the MIAC syndrome (8.54 cm(3)). TAC was highest among patients having all three components (179.2 HU) and lowest among those who do not have the MIAC syndrome (0 HU).We found a relationship between PFT and MIAC syndrome in ESRD patients.
- Subjects :
- Male
Nephrology
medicine.medical_specialty
Pathology
Turkey
Urology
medicine.medical_treatment
Population
Aortic Diseases
Gastroenterology
End stage renal disease
Peritoneal dialysis
chemistry.chemical_compound
Renal Dialysis
Risk Factors
Internal medicine
medicine.artery
Multidetector Computed Tomography
medicine
Humans
education
Retrospective Studies
Inflammation
Aorta
education.field_of_study
business.industry
Incidence
Malnutrition
Calcinosis
Middle Aged
respiratory system
Atherosclerosis
medicine.disease
respiratory tract diseases
C-Reactive Protein
Cross-Sectional Studies
Adipose Tissue
chemistry
Kidney Failure, Chronic
Uric acid
Female
Hemodialysis
business
Follow-Up Studies
Calcification
Subjects
Details
- ISSN :
- 15732584 and 03011623
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- International Urology and Nephrology
- Accession number :
- edsair.doi.dedup.....b49136772a9b9214970aa71160cfe444