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Assessing the Effect of Treatment Duration on the Association between Anti-Diabetic Medication and Cancer Risk
- Source :
- PLoS ONE, Vol 9, Iss 11, p e113162 (2014), PLoS ONE
- Publication Year :
- 2014
-
Abstract
- Most studies that have evaluated the association between anti-diabetic medication and cancer risk have suffered from methodological drawbacks. To avoid time-related biases, we evaluated the effect of treatment duration on the cancer risk among naive users of anti-diabetic medication as compared to non-users. In addition, we addressed the influence of common risk factors such as smoking and BMI. The study population comprised 23,394 participants of FINRISK surveys. Data on cancer and anti-diabetic medication were linked with the study cohorts. We applied Lexis tabulation to the data and analyzed split records by using Poisson regression. Changes in cancer incidence in relation to treatment duration were examined by modeling the rate ratio (RR). After a median follow-up of 9 years, 53 cancer cases among users of anti-diabetic medication and 1,028 among non-users were diagnosed. No significant difference in cancer risk between users and non-users was observed after adjustment. The RR for all medication regardless of its duration was 1.01 [95% CI 0.75–1.33], and 1.37 [0.94–1.94] for period of 1–4 years. The results were similar for metformin, sulfonylurea, and insulin. This study demonstrates that evaluation of the variation in cancer risk in relation to treatment duration is of particular importance for enhancing the accuracy of conclusions on the link between exposure to anti-diabetic medication and cancer risk.
- Subjects :
- Male
Time Factors
Cross-sectional study
Epidemiology
medicine.medical_treatment
lcsh:Medicine
Rate ratio
Body Mass Index
Cohort Studies
0302 clinical medicine
Mathematical and Statistical Techniques
Risk Factors
Neoplasms
Medicine and Health Sciences
Registries
lcsh:Science
Multidisciplinary
STATEMENT
Incidence
Middle Aged
FINLAND
3. Good health
PREVALENCE
030220 oncology & carcinogenesis
Cohort
Physical Sciences
Population study
DETECTION BIAS
Female
SMOKING
Risk assessment
BURDEN
Cancer Epidemiology
Statistics (Mathematics)
Cohort study
Research Article
Adult
medicine.medical_specialty
education
030209 endocrinology & metabolism
Research and Analysis Methods
Risk Assessment
Anti-diabetic medication
03 medical and health sciences
TYPE-2
Internal medicine
medicine
Diabetes Mellitus
Humans
Hypoglycemic Agents
COHORT
ALGORITHM
Statistical Methods
Aged
business.industry
Pharmacoepidemiology
MORTALITY
lcsh:R
Cancer
medicine.disease
Health Surveys
Surgery
Cross-Sectional Studies
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Metabolic Disorders
Multivariate Analysis
lcsh:Q
3111 Biomedicine
business
Mathematics
Follow-Up Studies
Generalized Linear Model
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, Vol 9, Iss 11, p e113162 (2014), PLoS ONE
- Accession number :
- edsair.doi.dedup.....b48dce79be17731f757613fb4f7b950d