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Clinical and pharmacokinetic drug evaluation of delafloxacin for the treatment of acute bacterial skin and skin structure infections
- Source :
- Expert opinion on drug metabolismtoxicology. 13(11)
- Publication Year :
- 2017
-
Abstract
- Introduction: In the era of multi-drug resistant pathogens, the adequate treatment of skin and skin structure infections remains a challenge for clinicians. Delafloxacin, with its broad spectrum against Gram-positive, Gram-negative and anaerobic organisms, represents a new therapeutic option in this setting, especially when coverage of methicillin-resistant Staphylococcus aureus is required in the empirical or targeted approach. Areas covered: In this drug evaluation, the Authors have reviewed the pharmacokinetic and pharmacodynamic characteristics of delafloxacin. In addition, recent data on clinical efficacy and safety from clinical trials have been included. Expert opinion: Delafloxacin represents an attractive therapeutic option due to a broad antimicrobial and favorable pharmacokinetic and pharmacodynamic profile. Several in vitro studies have demonstrated the low potential for resistance selection if used in empirical regimens. Delafloxacin is a promising candidate for the treatment of Gram-positive infections, especially if co-infection with other pathogens is suspected. This is because of the very low MIC of the agent for Gram-positive (including MRSA) and anaerobic bacteria and because of the wide spectrum of activity against Gram-negative organisms. For these interesting microbiological and PK/PD characteristics we expect future uses of this drug in other indications such as diabetic foot infection, osteomyelitis, prosthetic joint infections, abdominal infections and central nervous system infections.
- Subjects :
- 0301 basic medicine
Gram-Positive Bacterial Infection
Pharmacology
Toxicology
medicine.disease_cause
Delafloxacin
fluoroquinolones
methicillin-resistant Staphylococcus aureus
pharmacokinetic
skin and skin structure infection
chemistry.chemical_compound
0302 clinical medicine
Drug Resistance, Multiple, Bacterial
Medicine
030212 general & internal medicine
media_common
Microbial Sensitivity Test
Skin and skin structure infection
methicillin-resistant Staphylococcus aureu
General Medicine
Antimicrobial
Anti-Bacterial Agents
Staphylococcus aureus
Human
Fluoroquinolones
Drug
medicine.medical_specialty
media_common.quotation_subject
030106 microbiology
Microbial Sensitivity Tests
fluoroquinolone
Gram-Positive Bacteria
03 medical and health sciences
Anti-Bacterial Agent
Gram-Negative Bacteria
Gram-Negative Bacterial Infection
Animals
Humans
Intensive care medicine
Gram-Positive Bacterial Infections
Animal
business.industry
Skin Diseases, Bacterial
Methicillin-resistant Staphylococcus aureus
Clinical trial
chemistry
Pharmacodynamics
business
Gram-Negative Bacterial Infections
Subjects
Details
- ISSN :
- 17447607
- Volume :
- 13
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Expert opinion on drug metabolismtoxicology
- Accession number :
- edsair.doi.dedup.....b487f33cf931b3ab8cdcc05d89044018