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Incentive processing in Congenital Adrenal Hyperplasia (CAH): a reward-based antisaccade study
- Source :
- PSYCHONEUROENDOCRINOLOGY
- Publication Year :
- 2012
-
Abstract
- Little is known about how steroid hormones contribute to the beneficial effect of incentives on cognitive control during adolescent development. In this study, 27 adolescents with Congenital Adrenal Hyperplasia (CAH, mean age 15.6 years, 12 female), a disorder of cortisol deficiency and androgen excess, and 36 healthy participants (mean age 16.3 years, 18 female) completed a reward-based antisaccade task. In this mixed-saccade task, participants performed eye movements towards (prosaccades) or away (antisaccades) from a peripherally occuring stimulus. On incentive trials, monetary reward was provided for correct performance, while no such reward was provided on no-incentive trials. Consistent with the hypothesis, the results showed that healthy, but not CAH adolescents, significantly improved their inhibitory control (antisaccade accuracy) during incentive trials relative to no-incentive trials. These findings were not driven by severity of CAH (salt wasters vs. simple virilizers), individual hormone levels, sex, age-at-diagnosis, or medication type (dexamethasone vs. hydrocortisone). In addition, no significant differences between groups were found on orienting responses (prosaccades). Additional analyses revealed an impact of glucocorticoid (GC) dosage, such that higher GC dose predicted better antisaccade performance. However, this effect did not impact incentive processing. The data are discussed within the context of steroid hormone mediated effects on cognitive control and reward processing.
- Subjects :
- DISORDER
Male
STRESS
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Social Sciences
Audiology
Cortisol
law.invention
Androgen
EARLY STEROID ABNORMALITIES
Endocrinology
Cognition
Randomized controlled trial
law
ADOLESCENTS
DOPAMINE RELEASE
Testosterone
Young adult
Child
HIPPOCAMPAL-FORMATION
Adolescence
Psychiatry and Mental health
DEPRESSIVE STATE
Sex steroids
Female
Psychology
Glucocorticoid
medicine.drug
medicine.medical_specialty
Adolescent
Development
Article
Young Adult
Reward
Internal medicine
medicine
Reaction Time
Saccades
Humans
Congenital adrenal hyperplasia
INHIBITORY CONTROL
Biological Psychiatry
Hydrocortisone
SUPPRESSION
Motivation
Adrenal Hyperplasia, Congenital
Endocrine and Autonomic Systems
PERFORMANCE
medicine.disease
Steroid hormone
Antisaccade task
Psychomotor Performance
Subjects
Details
- Language :
- English
- ISSN :
- 03064530
- Database :
- OpenAIRE
- Journal :
- PSYCHONEUROENDOCRINOLOGY
- Accession number :
- edsair.doi.dedup.....b47fb12bab996d5f5a3f04ec879b0648