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A Systematic Review on Intensity Modulated Radiation Therapy for Mediastinal Hodgkin's Lymphoma
- Source :
- Critical reviews in oncology/hematology. 167
- Publication Year :
- 2020
-
Abstract
- Background Secondary malignant neoplasms (SMNs) and cardiovascular diseases induced by chemotherapy and radiotherapy represent the main cause of excess mortality for early-stage Hodgkin lymphoma patients, especially when the mediastinum is involved. Conformal radiotherapy techniques such as Intensity-Modulated Radiation Therapy (IMRT) could allow a reduction of the dose to the organs-at-risk (OARs) and therefore limit long-term toxicity. Methods We performed a systematic review of the current literature regarding comparisons between IMRT and conventional photon beam radiotherapy, or between different IMRT techniques, for the treatment of mediastinal lymphoma. Results and conclusions IMRT allows a substantial reduction of the volumes of OARs exposed to high doses, reducing the risk of long-term toxicity. This benefit is conterbalanced by the increase of volumes receiving low doses, that could potentially increase the risk of SMNs. Treatment planning should be personalized on patient and disease characteristics. Dedicated techniques such as “butterfly” VMAT often provide the best trade-off.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
lymphoma
intensity modulated
Mediastinal Neoplasms
conformal
Mediastinal Lymphoma
medicine
mediastinal
Humans
IMRT
Radiation treatment planning
radiotherapy
secondary cancer
Chemotherapy
business.industry
cardiovascular
Radiotherapy Planning, Computer-Assisted
Mediastinum
Radiotherapy Dosage
Hematology
Intensity-modulated radiation therapy
Hodgkin's lymphoma
medicine.disease
Hodgkin Disease
Lymphoma
Radiation therapy
medicine.anatomical_structure
Oncology
Radiology
Radiotherapy, Intensity-Modulated
Radiotherapy, Conformal
business
Subjects
Details
- ISSN :
- 18790461
- Volume :
- 167
- Database :
- OpenAIRE
- Journal :
- Critical reviews in oncology/hematology
- Accession number :
- edsair.doi.dedup.....b468ed2ecbe1076aa446c7460b5694cc