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Hierarchical bioresponsive nanocarriers for codelivery of curcumin and doxorubicin
- Source :
- Colloids and Surfaces B: Biointerfaces. 180:93-101
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Hierarchical responsive nanocarriers have received much attention for targeted delivery of chemotherapeutics. In this study, we designed pH and redox dual-stage responsive nanocarriers in the different delivery stages for co-delivery phosphorylated curcumin (p-Cur) with doxorubicin (Dox). The MSNs nanocarriers were functionalized via specific cleavable PEGylation and hydrogel coating crosslinked by disulfide bonds: MSNs as core load Dox; p-Cur encapsulated in hydrogel coating. In blood circulation, PEGylation endow the nanocarriers with long time during blood circulation; while in tumor tissue, PEG shells could be cleaved due to the pH-sensitive bond and expose the cationic hydrogel coating to improve cell uptake; while inside tumor cells, hydrogel coating could be cleaved due to the GSH and release the drugs. The results showed that the dual-responsive shells endowed the nanocarriers with tumor extracellular pH-triggered cell uptake and specific cancer cell target release. The synergistic effects of the p-Cur and Dox enhanced cellular apoptosis in Hela cells.
- Subjects :
- Curcumin
Cell Survival
Drug Compounding
Cell
Antineoplastic Agents
Apoptosis
macromolecular substances
02 engineering and technology
01 natural sciences
HeLa
chemistry.chemical_compound
Colloid and Surface Chemistry
0103 physical sciences
PEG ratio
medicine
Humans
Doxorubicin
Physical and Theoretical Chemistry
Drug Carriers
010304 chemical physics
biology
technology, industry, and agriculture
Surfaces and Interfaces
General Medicine
Hydrogen-Ion Concentration
021001 nanoscience & nanotechnology
biology.organism_classification
Drug Liberation
Kinetics
medicine.anatomical_structure
chemistry
Cancer cell
PEGylation
Biophysics
Nanoparticles
Nanocarriers
0210 nano-technology
Oxidation-Reduction
HeLa Cells
Biotechnology
medicine.drug
Subjects
Details
- ISSN :
- 09277765
- Volume :
- 180
- Database :
- OpenAIRE
- Journal :
- Colloids and Surfaces B: Biointerfaces
- Accession number :
- edsair.doi.dedup.....b46865a3113de73a389b08e7da6ad803