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White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities
- Source :
- Alber, J, Alladi, S, Bae, H-J, Barton, D A, Beckett, L A, Bell, J M, Berman, S E, Biessels, G J, Black, S E, Bos, I, Bowman, G L, Brai, E, Brickman, A M, Callahan, B L, Corriveau, R A, Fossati, S, Gottesman, R F, Gustafson, D R, Hachinski, V, Hayden, K M, Helman, A M, Hughes, T M, Isaacs, J D, Jefferson, A L, Johnson, S C, Kapasi, A, Kern, S, Kwon, J C, Kukolja, J, Lee, A, Lockhart, S N, Murray, A, Osborn, K E, Power, M C, Price, B R, Rhodius-Meester, H F M, Rondeau, J A, Rosen, A C, Rosene, D L, Schneider, J A, Scholtzova, H, Shaaban, C E, Silva, N C B S, Snyder, H M, Swardfager, W, Troen, A M, van Veluw, S J, Vemuri, P, Wallin, A, Wellington, C, Wilcock, D M, Xie, S X & Hainsworth, A H 2019, ' White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities ', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 5, pp. 107-117 . https://doi.org/10.1016/j.trci.2019.02.001, Alzheimer's & Dementia : Translational Research & Clinical Interventions
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including Alzheimer's disease [AD]). WMHs are also seen in cognitively healthy people. In this collaboration of academic, clinical, and pharmaceutical industry perspectives, we identify outstanding questions about WMHs and their relation to cognition, dementia, and AD. What molecular and cellular changes underlie WMHs? What are the neuropathological correlates of WMHs? To what extent are demyelination and inflammation present? Is it helpful to subdivide into periventricular and subcortical WMHs? What do WMHs signify in people diagnosed with AD? What are the risk factors for developing WMHs? What preventive and therapeutic strategies target WMHs? Answering these questions will improve prevention and treatment of WMHs and dementia.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
LATE-LIFE
BLOOD-PRESSURE
PROGRESSION
Disease
SMALL-VESSEL DISEASE
Vascular dementia
White matter lesions
03 medical and health sciences
0302 clinical medicine
Physical medicine and rehabilitation
medicine
Dementia
Brain magnetic resonance imaging
BRAIN
Cognitive impairment
LESIONS
business.industry
Leukoaraiosis
Cognition
medicine.disease
Hyperintensity
Small vessel disease
3. Good health
ALZHEIMERS-DISEASE
Psychiatry and Mental health
030104 developmental biology
Perspective
RISK-FACTORS
Vascular cognitive impairment
Neurology (clinical)
business
UNSELECTED COHORT
030217 neurology & neurosurgery
MRI
Subjects
Details
- Language :
- English
- ISSN :
- 23528737
- Database :
- OpenAIRE
- Journal :
- Alber, J, Alladi, S, Bae, H-J, Barton, D A, Beckett, L A, Bell, J M, Berman, S E, Biessels, G J, Black, S E, Bos, I, Bowman, G L, Brai, E, Brickman, A M, Callahan, B L, Corriveau, R A, Fossati, S, Gottesman, R F, Gustafson, D R, Hachinski, V, Hayden, K M, Helman, A M, Hughes, T M, Isaacs, J D, Jefferson, A L, Johnson, S C, Kapasi, A, Kern, S, Kwon, J C, Kukolja, J, Lee, A, Lockhart, S N, Murray, A, Osborn, K E, Power, M C, Price, B R, Rhodius-Meester, H F M, Rondeau, J A, Rosen, A C, Rosene, D L, Schneider, J A, Scholtzova, H, Shaaban, C E, Silva, N C B S, Snyder, H M, Swardfager, W, Troen, A M, van Veluw, S J, Vemuri, P, Wallin, A, Wellington, C, Wilcock, D M, Xie, S X & Hainsworth, A H 2019, ' White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities ', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 5, pp. 107-117 . https://doi.org/10.1016/j.trci.2019.02.001, Alzheimer's & Dementia : Translational Research & Clinical Interventions
- Accession number :
- edsair.doi.dedup.....b4652e44b6a626a3e8cf05b920c3e595
- Full Text :
- https://doi.org/10.1016/j.trci.2019.02.001