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Natural killer cells modulation in hematological malignancies
- Source :
- Frontiers in Immunology, Frontiers in Immunology, Frontiers, 2013, NK and lymphoid cell biology (4), pp.459. ⟨10.3389/fimmu.2013.00459⟩, Frontiers in Immunology, 2013, NK and lymphoid cell biology (4), pp.459. ⟨10.3389/fimmu.2013.00459⟩
- Publication Year :
- 2013
- Publisher :
- HAL CCSD, 2013.
-
Abstract
- International audience; Hematological malignancies (HM) treatment improved over the last years resulting in increased achievement of complete or partial remission, but unfortunately high relapse rates are still observed, due to remaining minimal residual disease.Therefore, sustainment of long-term remission is crucial, using either drug maintenance treatment or by boosting or prolonging an immune response. Immune system has a key role in tumor surveillance. Nonetheless, tumor-cells evade the specific T-lymphocyte mediated immune surveillance using many mechanisms but especially by the down-regulation of the expression of HLA class I antigens. In theory, these tumor-cells lacking normal expression of HLA class I molecules should be destroyed by natural killer (NK) cells, according to the missing-self hypothesis. NK cells, at the frontier of innate and adaptive immune system, have a central role in tumor-cells surveillance as demonstrated in the setting of allogenic stem cell trans-plantation. Nevertheless, tumors develop various mechanisms to escape from NK innate immune pressure. Abnormal NK cytolytic functions have been described in many HM. We present here various mechanisms involved in the escape of HM from NK-cell surveillance, i.e., NK-cells quantitative and qualitative abnormalities.
- Subjects :
- medicine.medical_treatment
Mini Review
[SDV]Life Sciences [q-bio]
Immunology
Human leukocyte antigen
03 medical and health sciences
0302 clinical medicine
Immune system
Medicine
Immunology and Allergy
hematological malignancies
030304 developmental biology
0303 health sciences
Innate immune system
natural killer cells
business.industry
immune escape
Immunotherapy
Acquired immune system
Minimal residual disease
3. Good health
Transplantation
[SDV] Life Sciences [q-bio]
immunotherapy
Stem cell
business
natural cytotoxicity receptors
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology, Frontiers in Immunology, Frontiers, 2013, NK and lymphoid cell biology (4), pp.459. ⟨10.3389/fimmu.2013.00459⟩, Frontiers in Immunology, 2013, NK and lymphoid cell biology (4), pp.459. ⟨10.3389/fimmu.2013.00459⟩
- Accession number :
- edsair.doi.dedup.....b45ab5014f1fb960a06740f09b125634