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Real-World Safety and Efficacy of Nivolumab in Advanced Squamous and Nonsquamous Non-Small-Cell Lung Cancer: A Retrospective Cohort Study in Croatia, Hungary and Malta
- Source :
- Journal of Oncology, Journal of Oncology, Vol 2020 (2020)
- Publication Year :
- 2020
- Publisher :
- Research Square Platform LLC, 2020.
-
Abstract
- Background. There is a lack of real-world data on the safety and efficacy of nivolumab in patients with previously treated advanced non-small-cell lung cancer (NSCLC) especially in South East Europe, a region with particularly high incidence and an unfavorable mortality-to-incidence ratio for lung cancer. Objectives. To evaluate the real-world safety and efficacy of nivolumab in patients with previously treated advanced squamous and nonsquamous NSCLC in South East Europe. Methods. This is a multicenter, retrospective cohort study on patients with stage IIIB or IV disease with at least one previous systemic treatment who received nivolumab through an expanded-access program between 2015 and 2017 in Croatia, Malta, and Hungary. The primary endpoint was the proportion of patients whose therapy was discontinued because of toxicity. Secondary endpoints were the incidence of adverse events (AEs), objective response rate (ORR), disease control rate (DCR), time to response (TTR), duration of response (DOR), progression-free survival (PFS), and overall survival (OS). Results. We analyzed data on 239 patients with a median (IQR) age of 62 (57–68), and 33% of them were women. Treatment was discontinued because of toxicity in 11.6% (95% CI 7.8% to 16.5%) of patients. The PFS was 6.4 (95% CI 5.2 to 8.6) months, and the median OS was 14.1 (10.6 to 18.0) months. Conclusions. The safety and efficacy of nivolumab in previously treated patients with advanced NSCLC in the real-world South East Europe clinical settings were consistent with the results of randomized clinical trials and comparable to the results from other countries.
- Subjects :
- medicine.medical_specialty
Article Subject
business.industry
Incidence (epidemiology)
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Retrospective cohort study
Disease
medicine.disease
law.invention
03 medical and health sciences
0302 clinical medicine
Oncology
Randomized controlled trial
law
030220 oncology & carcinogenesis
Internal medicine
Clinical endpoint
Medicine
030212 general & internal medicine
Nivolumab
business
Adverse effect
Lung cancer
RC254-282
Research Article
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Journal of Oncology, Journal of Oncology, Vol 2020 (2020)
- Accession number :
- edsair.doi.dedup.....b45067c1c36061ab31fc465ceb484991