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Comparison of the Responses to Thrombin in Monkey Renal and Uterine Arteries
- Source :
- Journal of the Society for Gynecologic Investigation. 9:146-151
- Publication Year :
- 2002
- Publisher :
- Springer Science and Business Media LLC, 2002.
-
Abstract
- Thrombin is known to regulate vascular tone. We analyzed and compared mechanisms of thrombin action in primate renal and uterine arteries.Isolated Japanese monkey renal and uterine arteries were suspended in Ringer-Locke solution for tension recordings.Renal arteries responded to thrombin with relaxation, which was inhibited by N(G)-nitro-L-arginine or indomethacin and reversed to contractions by the combination. The relaxations were also reversed to contractions by endothelial denudation. Conversely, thrombin caused uterine arterial contractions that were unaffected by endothelial denudation. Relaxations in both renal arteries and contractions in uterine arteries were suppressed by hirudin (a specific thrombin inhibitor). Relaxant responses to A23187 (Ca(2+) ionophore), nitroprusside sodium (nitric oxide donor), and beraprost sodium (prostacyclin analogue) did not differ between renal and uterine arteries.Thrombin-induced relaxation of renal arteries appears to be mediated by nitric oxide and vasodilator prostaglandins liberated from the endothelium, whereas uterine arterial contraction is caused by an endothelium-independent mechanism.
- Subjects :
- Nitroprusside
medicine.medical_specialty
Endothelium
Muscle Relaxation
Vasodilator Agents
Indomethacin
Hirudin
Prostacyclin
Nitroarginine
Nitric oxide
chemistry.chemical_compound
Renal Artery
Thrombin
Isometric Contraction
medicine.artery
Internal medicine
medicine
Animals
Renal artery
Uterine artery
Calcimycin
business.industry
Uterus
Obstetrics and Gynecology
Arteries
Anatomy
Epoprostenol
medicine.anatomical_structure
Endocrinology
chemistry
Organ Specificity
Macaca
Female
Endothelium, Vascular
Sodium nitroprusside
business
medicine.drug
Subjects
Details
- ISSN :
- 10715576
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Journal of the Society for Gynecologic Investigation
- Accession number :
- edsair.doi.dedup.....b44dea67f8d8c29287db719d6fdb6231