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Grading Ductal Carcinoma In Situ (DCIS) of the Breast – What’s Wrong with It?
- Source :
- Pathology Oncology Research
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Ductal carcinoma in situ of the breast is a non-obligate precursor of invasive breast cancer, and at its lower risk end might not need treatment, a hypothesis tested in several currently running randomized clinical trials. This review describes the heterogeneity of grading ductal carcinoma in situ (DCIS). First it considers differences between low and high grade DCIS, and then it looks at several grading schemes and highlights how different these are, not only in the features considered for defining a given grade but also in their wording of a given variable seen in the grade in question. Rather than being fully comprehensive, the review aims to illustrate the inconsistencies. Reproducibility studies on grading mostly suggestive of moderate agreement on DCIS differentiation are also illustrated. The need for a well structured, more uniform and widely accepted language for grading DCIS is urged to avoid misunderstanding based misclassifications and improper treatment selection. Electronic supplementary material The online version of this article (10.1007/s12253-019-00760-8) contains supplementary material, which is available to authorized users.
- Subjects :
- 0301 basic medicine
Cancer Research
medicine.medical_specialty
Grade
Breast Neoplasms
Review
Pathology and Forensic Medicine
03 medical and health sciences
Breast cancer
0302 clinical medicine
Need treatment
Ductal carcinoma in situ (DCIS)
medicine
Humans
skin and connective tissue diseases
Grading (tumors)
business.industry
Ductal carcinoma in situ
General Medicine
Ductal carcinoma
medicine.disease
Carcinoma, Intraductal, Noninfiltrating
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Female
Radiology
Neoplasm Grading
business
Subjects
Details
- ISSN :
- 15322807 and 12194956
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Pathology & Oncology Research
- Accession number :
- edsair.doi.dedup.....b43e263f142e1be496876b66b29e32de