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Inhibition of MDM2-p53 feedback loop by various small molecules for potential cancer chemotherapy
- Source :
- Cancer Biology & Therapy. 7:853-855
- Publication Year :
- 2008
- Publisher :
- Informa UK Limited, 2008.
-
Abstract
- Commentary to:A small molecule that disrupts Mdm2-p53 binding activates p53, induces apoptosis, and sensitizes lung cancer cells to chemotherapy Steven H. Sun, Min Zheng, Ke Ding, Shaomeng Wang, Yi Sun
- Subjects :
- Cancer Research
Pathology
medicine.medical_specialty
Indoles
Lung Neoplasms
Cancer chemotherapy
medicine.medical_treatment
Antineoplastic Agents
Apoptosis
Mice
Cell Line, Tumor
medicine
Animals
Humans
Spiro Compounds
Mdm2 p53
skin and connective tissue diseases
Lung cancer
Pharmacology
Chemotherapy
integumentary system
business.industry
Drug Synergism
Proto-Oncogene Proteins c-mdm2
medicine.disease
Small molecule
Gene Expression Regulation, Neoplastic
Oncology
Cancer research
Molecular Medicine
Tumor Suppressor Protein p53
business
Subjects
Details
- ISSN :
- 15558576 and 15384047
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Cancer Biology & Therapy
- Accession number :
- edsair.doi.dedup.....b43900f944b92fb76c82092f2a88a285
- Full Text :
- https://doi.org/10.4161/cbt.7.6.6196