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Triterpenoid Saponins From the Roots of Gypsophila Trichotoma Wender
- Source :
- Phytochemistry, Phytochemistry, Elsevier, 2013, pp.114-127. ⟨10.1016/j.phytochem.2013.03.001 ⟩, Phytochemistry, Elsevier, 2013, 90, pp.114-127. ⟨10.1016/j.phytochem.2013.03.001⟩, Phytochemistry, Elsevier, 2013, pp.114-127. ⟨10.1016/j.phytochem.2013.03.001⟩
- Publication Year :
- 2013
- Publisher :
- HAL CCSD, 2013.
-
Abstract
- International audience; Eleven triterpenoid saponins were isolated from the roots of Gypsophila trichotoma Wender. (G. trichotoma Wender. var. trichotoma) (Caryophyllaceae), together with one known compound. The structures were established on the basis of extensive NMR analysis ((1)H, (13)C NMR, COSY, TOCSY, ROESY, HSQC, and HMBC), completed by analysis of HR-ESI-MS and ESI-MS(n). The saponins have the commonly found gypsogenin as the aglycone substituted at C-3 with trisaccharide and at C-28 with oligosaccharide through a fucose residue, as saponins isolated from Gypsophila perfoliata L. originated from China. The oligosaccharide attached to C-28 is substituted with acetyl and (or) sulfate groups. Тhe cytotoxicity of the saponin extract from G. trichotoma was evaluated against a rat alveolar macrophage-like cell line NR8383 and human leukemia cell lines U937 and BV-173. The synergistic effect of the aminoacyl saponins, previously isolated from G. trichotoma, was tested for its ability to enhance the cytotoxicity of the targeted toxin in HER14 cells.
- Subjects :
- food.ingredient
Gypsophila
Stereochemistry
Cell Survival
Saponin
Drug Evaluation, Preclinical
Molecular Conformation
Caryophyllaceae
Plant Science
Horticulture
01 natural sciences
Biochemistry
Plant Roots
Fucose
Cell Line
chemistry.chemical_compound
Structure-Activity Relationship
food
Animals
Humans
[CHIM]Chemical Sciences
Trisaccharide
Molecular Biology
Cell Proliferation
chemistry.chemical_classification
biology
Dose-Response Relationship, Drug
010405 organic chemistry
General Medicine
U937 Cells
Oligosaccharide
Saponins
biology.organism_classification
Triterpenes
0104 chemical sciences
Rats
010404 medicinal & biomolecular chemistry
Aglycone
chemistry
Gypsophila perfoliata
Subjects
Details
- Language :
- English
- ISSN :
- 00319422
- Database :
- OpenAIRE
- Journal :
- Phytochemistry, Phytochemistry, Elsevier, 2013, pp.114-127. ⟨10.1016/j.phytochem.2013.03.001 ⟩, Phytochemistry, Elsevier, 2013, 90, pp.114-127. ⟨10.1016/j.phytochem.2013.03.001⟩, Phytochemistry, Elsevier, 2013, pp.114-127. ⟨10.1016/j.phytochem.2013.03.001⟩
- Accession number :
- edsair.doi.dedup.....b42e5dc5201ee97ab285899ee8b84794