Back to Search
Start Over
Molecular Mechanisms Underlying Cardiac Adaptation to Exercise
- Source :
- Cell Metabolism. 25:1012-1026
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Exercise elicits coordinated multi-organ responses including skeletal muscle, vasculature, heart, and lung. In the short term, the output of the heart increases to meet the demand of strenuous exercise. Long-term exercise instigates remodeling of the heart including growth and adaptive molecular and cellular re-programming. Signaling pathways such as the insulin-like growth factor 1/PI3K/Akt pathway mediate many of these responses. Exercise-induced, or physiologic, cardiac growth contrasts with growth elicited by pathological stimuli such as hypertension. Comparing the molecular and cellular underpinnings of physiologic and pathologic cardiac growth has unveiled phenotype-specific signaling pathways and transcriptional regulatory programs. Studies suggest that exercise pathways likely antagonize pathological pathways, and exercise training is often recommended for patients with chronic stable heart failure or following myocardial infarction. Herein, we summarize the current understanding of the structural and functional cardiac responses to exercise as well as signaling pathways and downstream effector molecules responsible for these adaptations.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Physiology
medicine.medical_treatment
030204 cardiovascular system & hematology
Biology
Cardiovascular System
Article
Cardiovascular Physiological Phenomena
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Animals
Humans
Gene Regulatory Networks
Myocardial infarction
Exercise physiology
Exercise
Molecular Biology
PI3K/AKT/mTOR pathway
Myocardium
Growth factor
Skeletal muscle
Heart
Cell Biology
medicine.disease
Cardiovascular physiology
030104 developmental biology
Endocrinology
medicine.anatomical_structure
Cardiovascular Diseases
Heart failure
Signal transduction
Neuroscience
Metabolic Networks and Pathways
Subjects
Details
- ISSN :
- 15504131
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Cell Metabolism
- Accession number :
- edsair.doi.dedup.....b42c6b72dfdad8870a3395036a821287