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Synthesis, Antifungal Activities and Qualitative Structure Activity Relationship of Carabrone Hydrazone Derivatives as Potential Antifungal Agents
- Source :
- International Journal of Molecular Sciences; Volume 15; Issue 3; Pages: 4257-4272, International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 15, Iss 3, Pp 4257-4272 (2014)
- Publication Year :
- 2014
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2014.
-
Abstract
- Aimed at developing novel fungicides for relieving the ever-increasing pressure of agricultural production caused by phytopathogenic fungi, 28 new hydrazone derivatives of carabrone, a natural bioactive sesquisterpene, in three types were designed, synthesized and their antifungal activities against Botrytis cinerea and Colletotrichum lagenarium were evaluated. The result revealed that all the derivatives synthesized exhibited considerable antifungal activities in vitro and in vivo, which led to the improved activities for carabrone and its analogues and further confirmed their potential as antifungal agents.
- Subjects :
- structure–activity relationship
Antifungal Agents
Hydrazone
lcsh:Chemistry
Solanum lycopersicum
lcsh:QH301-705.5
Spectroscopy
Botrytis cinerea
chemistry.chemical_classification
Colletotrichum lagenarium
carabrone
Molecular Structure
structure-activity relationship
General Medicine
Spores, Fungal
Computer Science Applications
Fungicide
hydrazone derivatives
Host-Pathogen Interactions
Botrytis
chemical modification
Antifungal
food.ingredient
Stereochemistry
medicine.drug_class
Microbial Sensitivity Tests
Biology
Catalysis
Article
Inorganic Chemistry
Inhibitory Concentration 50
food
Species Specificity
medicine
Colletotrichum
Structure–activity relationship
Physical and Theoretical Chemistry
Molecular Biology
Mycelium
Organic Chemistry
antifungal activity
fungi
Hydrazones
biology.organism_classification
Combinatorial chemistry
chemistry
lcsh:Biology (General)
lcsh:QD1-999
Models, Chemical
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences; Volume 15; Issue 3; Pages: 4257-4272
- Accession number :
- edsair.doi.dedup.....b42b9643b68ab647dc91f2ec50ceb992
- Full Text :
- https://doi.org/10.3390/ijms15034257